Stem cell injection actually grows alveolar bone, can tooth regeneration become a reality?

In a person's life, the first deciduous tooth grows in about 6 months, and the germination of 20 subdivided deciduous teeth is completed at about 20 and a half years old. At the age of 6-7, deciduous teeth fell off and 32 permanent teeth gradually erupted. Then, due to aging and disease, teeth are left to us one by one. The use of stem cells to repair teeth has been successful. It is reported that from 2065438 to August 2008, the Stomatological Hospital of Air Force Military Medical University (formerly the Fourth Military Medical University) successfully realized the functional regeneration of whole dental pulp tissue by using deciduous teeth stem cells, thus treating oral diseases more advanced. Enter a new milestone.

At present,? Root canal therapy? It is the main method for clinical treatment of pulp diseases: firstly, the pulp cells in the pulp cavity and root canal are completely removed and filled with biomaterials. However, this method is due to the destruction of the pulp. Teeth have no nutritional supply. Although the teeth will remain after filling, they will gradually become brittle and discolored, and they will be easily broken when biting hard objects. In order to cope with the international problem of pulp regeneration of upper teeth, the research team of Stomatological Hospital of Air Force Military Medical University has made efforts for more than 20 years to obtain dental pulp stem cells from deciduous teeth. After in vitro culture, the formed stem cell aggregates were implanted into the teeth needed by patients. In the marrow cavity, the nerves and blood vessels of the teeth are regenerated, and the original functions of the teeth are completely restored. Especially for young patients with developing teeth, teeth can develop to a normal state.

Stem cells in children's deciduous teeth are useful. It can be understood that stem cells are seed cells with self-replication and multi-directional differentiation potential. Since the discovery of stem cells by 196 1, stem cells have been one of the most important research objects in regenerative medicine. As a rising star in the stem cell family, dental pulp stem cells of deciduous teeth can differentiate into many kinds of cells under specific induction conditions, which has broad application prospects in the medical field. In addition, dental pulp stem cells of deciduous teeth can secrete dozens of cytokines or active proteins, such as immunomodulatory factors, nerve regeneration factors, angiogenesis factors and so on. They can also rely on chemical signals released by the microenvironment of diseased or damaged tissues and chemotaxis of their own secretions. Influencing factors, migration to the lesion and injury site, and participation in tissue repair.

Therefore, deciduous teeth stem cells are ideal seed cells. At present, deciduous teeth stem cells have been used in the research of pulp regeneration, periodontal regeneration, central nervous system injury, neurodegenerative diseases, corneal regeneration, myocardial infarction, liver fibrosis, rheumatoid arthritis, bone and cartilage regeneration and Du Xing's muscle therapy all over the world. Malnutrition, systemic immune diseases, endocrine diseases, acute respiratory distress, autoimmune encephalomyelitis and acute renal failure.