The research on the pathogenesis of Bunia virus has made progress. What's the new progress? How to understand?

SFTSV is a new Bunia virus, 20 10 was first discovered in China, belonging to the genus Physopa. Sfttsv is a single-stranded negative RNA virus that can cause fever with thrombocytopenia syndrome (SFTS). The main clinical manifestations are high fever, thrombocytopenia, leukopenia and multiple organ dysfunction, and the mortality rate can be as high as 6.3% ~ 30%.

More dangerously, SFTSV infection has recently been found in pets. In recent years, the incidence of SFTS has expanded to at least 15 provinces in China, and the disease has also been found in Asian countries such as South Korea, Japan and Vietnam, indicating that the epidemic scope is expanding and there is still the risk of outbreak. So far, there is no special treatment for fever with thrombocytopenia. Because of the great threat of SFTSV to public health, it has aroused widespread concern in the field of virology.

Recently, Professor Wu Zhiwei of Medical College has successfully developed a camel nano-monoclonal antibody against SFTSV based on immunological research, which has attracted market attention. This is a great progress in the treatment of SFTSV infection. On 20 14, the research team led by Professor Wu Zhiwei of Nanjing University began to study the new Bunia virus. Based on clinical virology, the research group made a comprehensive study on the clinical manifestations, viral load, cytokine regulation, serum interferon level, immune-related gene expression in peripheral blood and dynamic changes of dendritic cells in patients with acute SFTSV infection [1].

Subsequently, the research team investigated the interaction between SFTSV and the host immune system, and noticed that uncontrolled high-level viremia was the most critical factor leading to serious infection and death of SFTSV. Severe and dead patients have serious humoral immune deficiency, which leads to a serious lack of nucleocapsid and envelope glycoprotein antibodies. This serious humoral immune deficiency will lead to uncontrollable virus replication and high level of viremia, and eventually lead to cytokine storm, thrombocytopenic coagulation dysfunction, and finally lead to multiple organ diseases, failure and death.