Pharmacokinetics of gemcitabine hydrochloride

After intravenous injection, this product is quickly distributed in various tissues in the body. The longer the infusion time, the wider and deeper the distribution volume and the longer the half-life. The t 1/2 of this product is about 32 ~ 94min； after a short time of infusion. Within 5 minutes after the end of infusion, the peak blood concentration of this product was 3.2 ~ 45.5 μ g/ml; Only a few of this product combine with protein, which can be rapidly and completely metabolized by cytidine in liver, kidney, blood and other tissues, and less than10% of the original drugs and metabolites are excreted in urine; The total clearance rate was 29.2 ~ 92.2 L/(h m2), which was related to sex and age (individual difference was 52.2%).

Indications: locally advanced or metastatic non-small cell lung cancer, pancreatic cancer, bladder cancer, breast cancer and other solid tumors.