Does Honda cbr650r hurt the engine when changing ecu?

Under normal circumstances, change the ecu without moving the throttle. Equivalent to the previous carburetor. If you move, the four levers are unbalanced, and four throttles are equivalent to four carburetors. If it moves, it will be unbalanced, and uneven work will lead to cylinder release. These things can't be moved, which will cause engine damage.

The modified ecu and air intake have nothing to do with this cylinder, because this cylinder is unstable for a long time, and the air leakage of the valve will cause the imbalance of the four cylinders.