Chinese medicine formula granules Characteristics (First Aid)

Summary: "Chinese medicine formula granules" is also known as Chinese medicine granules, decoction-free tablets, single-flavored Chinese medicine concentrated granules. As a new type of soup replacing traditional Chinese medicine tablets, it is convenient, fast, safe, hygienic and scientific. Its successful development has received attention and high evaluation from all walks of life. With the development and progress of the society and the improvement of human's health requirements, higher requirements will be put forward to the cause of traditional Chinese medicine, so the survival and development strategy of "Chinese medicine formula particles" based on the premise of market and scientific research and development, with production efficiency as the breakthrough point, and quality of the process as the guarantee will be a fruitful result.

Keywords: Chinese medicine formulated particles, advantages, disadvantages, research progress

"Chinese medicine formulated particles" refers to in accordance with the method of Chinese medicine preparation leaching, the selection of appropriate solvents and procedures: hemorrhoidal Chinese medicine tablets of soluble active ingredients leaching, concentration and drying, according to a certain proportion of the bulk or granules made. The implementation of single-flavored quantitative packaging, for pharmacists to follow the medical advice with the prescription, according to the prescribed dosage allocation to the patient to take directly." Chinese medicine formula particles" do not need to be decocted, that is served that is flushed, the traditional Chinese medicine soup, into a fast, simple, convenient, hygienic dosage form, is an attempt to reform the Chinese medicine soup.

The introduction of "Chinese medicine formula particles" is the inevitable trend of the reform of Chinese medicine soup and modernization of Chinese medicine. Through the author was included in the State Administration of Traditional Chinese Medicine scientific research projects of several scientific research units on the subject of demonstration, experimental analysis, data processing, theoretical summaries, pilot testing of samples, large-scale production and clinical use of some of the situation to understand, and deepen the understanding of the "Chinese medicine formula particles". We believe that "Chinese medicine formula particles" has many advantages:

1. Mechanized large-scale production, better than the traditional decoction." Chinese medicine formula granules" instead of Chinese medicine tablets for clinical use, thus fundamentally changing the thousands of years of Chinese medicine tablets to roots, stems, leaves, flowers, fruits, etc. directly into the medicine decoction method. The mechanized production of Chinese medicine free of decoction tablets is based on the nature of the single obscurantist Chinese medicine, which is extracted under different conditions of humidity, time, PH value, etc., the highest content of the active ingredient as a standard, with advanced production equipment and stable production process made of powder. Patients can take it directly, avoiding the traditional soups being decocted by patients themselves, who do not know much about the amount of water to be added, soaking time, fire, decocting time, decocting first, decocting second, etc. or are afraid of trouble, and do not decoct according to the requirements, which affects the therapeutic effect. Mechanization of scientific production of Chinese medicine formula granules not only to ensure the quality of the finished product, but also to avoid interactions between drugs, reduce the loss of heat-resistant components, etc., thus ensuring the efficacy of Chinese medicine.

2. Unified quality standards to ensure the efficacy of "Chinese medicine formula particles" should be designated by the health administrative department of the fixed pharmaceutical production. From the origin of the raw materials, quality, transportation, storage, etc. should have a set of management regulations, for each kind of medicine according to the nature of its active ingredients, the development of the production process, quality standards and testing methods, the development of a decoction-free tablets and Chinese medicine tablets of the dosage of the two between the conversion relationship. The production of decoction-free tablets of traditional Chinese medicine should be scientifically managed, quality standards should be unified, and every link should be strictly controlled to ensure clinical efficacy. With the expansion of the market, market demand increases, manufacturers can be based on the local climate, environmental conditions, choose suitable for the local growing environment of the herbs, with their own cultivation, planting bases, from planting, harvesting, shelling and processing to the mechanization of the production of decoction-free tablets in one-stop, so that the cost will be greatly reduced, the price will be more acceptable to the patient, the quality of the finished product, the efficacy of the product has been guaranteed.

3. Convenient to take, carry "Chinese medicine formula particles" by scientific treatment, take without decoction, just according to the physician's prescription to boil water can be taken, thus reducing manpower, saving time, convenient for patients to take. Due to its small size, it is more convenient to carry, which is most suitable for patients who take it on the way and those who are busy at work and do not have time to decoct. Emergency patients also take with the service.

4. Convenient for storage, deployment "Chinese medicine formula granules" using aluminum bag packaging, moisture is not easy to absorb, to avoid the Chinese medicine storage, storage, improper storage brought about by the oil, discoloration, insect moths, mildew, and other quality problems, reduce pollution, convenient storage. Because of its bags are marked with the original drug conversion relationship, mixing more convenient, hygienic and fast, can avoid the traditional Chinese medicine hand grasp, weighing and weighing brought about by the sub-dosage error, but also changed the traditional Chinese medicine room to the dirty, messy, tired of the phenomenon.

5. The use of Chinese medicine formula particles preparation of punch The use of Chinese medicine formula preparation of punch is according to the prescription to take the equivalent of the weight of the original medicine free of decoction tablets mixed, according to the appropriate proportion of dextrin and other excipients, according to the requirements of the preparation of material preparation of soft materials, placed in the granulation machine granulation. This method of preparation of punch saves time and labor, hygiene, fast and convenient. It eliminates the process of decoction, concentration, alcohol precipitation of traditional Chinese medicine, shortens the preparation time, saves energy, equipment and the use of ethanol, and is not subject to the limitations of the time of decoction, can be prepared at any time.

The development of "Chinese medicine formula particles" has promoted the scientific and technological progress of the traditional Chinese medicine industry, played a great role in promoting the competition of traditional Chinese medicine in the international market, and also refreshed the way of medication and the concept of our traditional soup.

"Chinese medicine formula particles" as a substitute for traditional tablets has also left us with some problems that are worth exploring further: the focus of the problem is that the clinical efficacy of Chinese medicine soup dose is often reflected in the comprehensive effect of the combination and the overall effect. Chinese medicine soup between multiple drugs, in the traditional modulation "*** decoction" process, can produce a series of physical and chemical changes, to promote each other, mutual constraints, to enhance the efficacy of the purpose of moderating the medicinal properties, give full play to the Chinese medicine formula of the role of the drugs, and "Chinese medicine formula particles" does not have the following advantages.

1. Chinese medicine "*** decoction" can change the solubility of the active ingredients of the tablets solubility is different, the drug efficacy is different. Studies have shown that dextrinized starch has the effect of increasing the solubility of phenolic drugs such as rutin and quercetin. In 1% Ge starch solution, the solubility of rutin is 3.8 times that of pure water. In the same conditions quercetin up to 6.5 times (kudzu starch concentration of 0.5% -2%, independent of the variety of starch). Paste starch can increase the solubility of phenolic drugs is due to a long time in the "*** decoction" process, the formation of "starch - rutin" complex. The study on the flavonoid content of licorice in the decoction of licorice and epiphyllum showed that the flavonoid content of the decoction of the two drugs was significantly higher than that of the single decoction of licorice, with the content of the single decoction of 1.18% and the content of the decoction of the combined decoction of 1.85%. Another on 4 kinds of different process preparation of Huanglian detoxification soup in gardenia glycoside content of the study results show that, Huanglian, Huangbai, Huangzen, gardenia 4 flavor Chinese medicine, using traditional method of decoction of total gardenia glycoside of the extraction rate of 97.4%, while 4 medicine respectively separate extraction after the merger of the samples, total gardenia glycoside of the extraction rate of 64.3%.

2. Chinese medicine **** decoction can change the taste of the drug Huanglian, Huangbai and rhubarb, licorice combined can change the bitter taste of small cork alkaloids type alkaloids. Some people on the "Typhoid Fever" and "The Essentials of the Golden Chamber" in the 12 containing Huanglian formula, each according to the recorded method of modulation, the results proved that the formula contains rhubarb, licorice soup, small cork alkaloids alkaloids alkaloids bitter taste have disappeared: and does not contain rhubarb, licorice soup, there is a small cork alkaloids alkaloids alkaloids a strong taste. The reason is: rhubarb, licorice and Huanglian **** decoction process, the generation of a yellow-brown tannic acid corky alkaloids and yellow to corky alkaloids - single licorice saponin salts of the gelatinous precipitate, this precipitate is physiologically active substances, which not only eliminates the corky bitterness, but also increased its solubility, after taking the body can produce pharmacological effects, does not belong to the contraindications of the pairing. And free of decoction drink tablets of similar drugs mixed, bitter flavor without obvious change.

3. Chinese medicine "*** decoction" can reduce the toxicity of some drugs, enhance its efficacy experimental evidence, the epiphyllum is used alone, its cardiac effect is neither obvious, nor persistent, and there is a toxicity. But in the traditional "*** decoction" of the "four against the soup", although dry ginger, licorice, no cardiac effects, but in the combination of cardiac effects after the enhancement of persistent, toxicity decreased, and the toxicity of the oral epiphyllum than the "four against the soup" 4. 1 times greater. Experiments also showed that the toxicity of dried ginger, licorice and epiphyllum was still equivalent to that of epiphyllum alone after decoction and mixing, or after single decoction and sequential administration. This suggests that the toxicity of "Four Reverses Tang" is reduced. It is due to the epiphyllum alkaloids and dry ginger, licorice in the "*** decoction" process to produce chemical changes.

4. Chinese medicine "*** decoction" can reduce the bacterial resistance Through the Huanglian single formula and the combination of drug resistance comparison experiments, proved that the single formula resistance is much higher than the combination. For example, the individual Huanglian and Huanglian Xieyu Tang in the same conditions inoculated with bacterial culture, bacteria can be in Huanglian higher than the experimental concentration of 32 times the case of growth, while Huanglian Xieyu Tang only 4 times higher. The experimental results showed that the resistance of Huanglian alone was 8 times greater than that of Huanglian Xieyu Tang. Therefore, the clinical efficacy of "formulated granules" after simple mixing is definitely not equivalent to that of traditional Chinese medicine soup.

Research Progress

At present, the research on the comparison of decoction-free traditional Chinese medicine and traditional soup is still relatively small, one of the reasons is that decoction-free traditional Chinese medicine is only dispersed in a few factories in Jiangsu, Hebei, and Guangdong for trial production, and there is no uniform quality standard: secondly, it is limited to the comparative clinical efficacy of the relatively large number of studies, and the physicochemical qualitative and quantitative research is very little; thirdly, it is in favor of or opposed to decoction-free traditional Chinese medicine, and it is unlikely to reach a consensus on the clinical effect. It is not possible to reach a **** knowledge for the time being. Therefore, it is really important to strengthen the research.

The most representative report on the study of single decoction mixing and combined decoction is the article of Mr. Si-Tong Yuan and other three people on the "Effect of combined decoction on dissolution effect of traditional Chinese medicine compound soup", which focuses on the research results in recent years. Most of the reactions in the process of compound decoction are "solubilization", "adsorption", "precipitation" and other effects on the dissolution rate of the components of traditional Chinese medicine, while "complexation", "hydrolysis", "polymerization", "dissociation" are relatively few, and the redox reaction is even less, the probability of generating new substances is extremely low, and the generation of new substances has very stringent condition requirements. Other authors have studied that the mixture of single decoction is better than combined decoction in five kinds of soup such as Huanglian Tang. The single decoction of Yin Qiao Xie Du Tang is superior to the combined decoction.

In Germany, botanical compounding is the preparation of various single drug extracts. In Japan, decoction-free herbal medicine was already used in the 1960s: this practice is also recognized in the FDA's draft botanicals. For quality control, Germany uses quantitative control of the active ingredient of single-flavored medicines, plus other indicators, and for those whose active ingredient is not known, in addition to the common indicators, the fingerprinting method is used for monitoring.

"Chinese medicine formula granules" is a product with an unlimited life cycle, which is incomparable to any new drug. With the passage of time, each concentrated granule will shine on the stage of medicine at home and abroad without the fear of being eliminated. Thus, it is expected to become China's traditional Chinese medicine industry in the 21st century and the expansion of foreign trade, boosting domestic demand, pulling the development of related industries, including the beverage processing industry, a point of contact.

We are convinced that "Chinese medicine formula particles" in the process of modernization, industrialization, will be able to make its due contribution to the cause of human health.

Source: China Entertainment Network (www.yule.com.cn) Original: /html/archive/2003/06/200306101040220.htm