Key tasks of the Twelfth Five-Year Plan for the development of medical science and technology

(a) the development of cutting-edge technology, leading the development of medicine.

Grasp the development trend of frontier fields of science and technology, take the development of frontier technologies such as biology, information, materials, engineering and nanotechnology as the guide, strengthen the interdisciplinary integration, vigorously promote the transformation of frontier technologies into medical applications, and strive to occupy a place in the frontier fields of international medical science and technology and lead the development of medical science and technology.

Development priorities:

1. omics technology. Develop genomics technologies such as genomics, transcriptomics, protein genomics, metabonomics, epigenetics and structural genomics, accelerate the development of next-generation sequencing technology, Qualcomm sample analysis technology, micro-sample extraction and amplification technology and massive data analysis technology, and promote the application of genomics technology in disease prevention and treatment.

2. Systems biotechnology. Development of medical informatics, bioinformatics and computational biology technology, research and development of Qualcomm quantitative biomedical data analysis and text mining technology, building a large-scale biomedical data fusion analysis platform, supporting the genome structure variation of major diseases and disease pathogenicity correlation analysis, epigenome and molecular typing research.

3. Nanomedical technology. Research on core key technologies and products such as nano medical materials, drug targeted delivery nano carriers, nano biological devices and nano diagnostic reagents; Study on biological effect mechanism and safety evaluation of nano-medical products.

4. Stem cells and regenerative medicine technology. To study the differentiation and development technologies of embryonic stem cells, adult stem cells and induced pluripotent stem cells (iPS), as well as the key technologies of stem cell therapy such as isolation, identification, amplification, identification, implantation into human body and immune rejection; To study the key technologies of regenerative medicine such as the construction and preservation of tissue engineering medical products.

5. Medical engineering technology. Develop new electromagnetic function detection and analysis technology, high-resolution medical imaging technology, molecular biomedical diagnosis technology, medical implant/interventional body technology, individualized surgery planning, navigation and positioning technology based on multimodal fusion images, and traditional Chinese medicine biomedical engineering technology combining modern science with traditional medical theory.

(2) Pay attention to basic research and solve scientific problems.

In order to solve the key scientific problems of human health and disease prevention, it is necessary to study and clarify the essence of life process, explore the law of disease occurrence and development, profoundly reveal the theoretical basis and scientific connotation of traditional medicine in understanding life and disease, and strive to make breakthroughs in the physiological and pathological process of life activities, the mechanism of disease occurrence and development and the basic theoretical research of prevention and treatment, so as to provide theoretical and technical basis for disease prevention and health promotion.

Development priorities:

1. Basic research on chronic non-communicable diseases. Carry out basic research on the prevention, diagnosis and treatment of cardiovascular and cerebrovascular diseases, malignant tumors, metabolic diseases, mental and nervous system diseases, immune diseases and other chronic diseases, clarify the etiology and prognosis of the diseases, and study the molecular and cellular mechanisms of the disease.

2. Basic research on infectious diseases. Study the epidemic characteristics, pathogenesis, diagnosis and treatment of infectious diseases, as well as the basic scientific problems of vaccine and drug research and development, and develop new strategies for monitoring, early warning, prevention, diagnosis and treatment of infectious diseases.

3. Basic research on individual development. To study the spatio-temporal specific regulation mechanism of gene expression, the mechanism of life phenomena such as cell division, migration and apoptosis in the process of individual development and regeneration, the regulation mechanism of development time course, the reproduction and verification of individual genetic development mechanism by model organisms and animal models, and the molecular mechanism of infant's intellectual development and physiological and physiological function development.

4. Basic research on aging and aging-related diseases. Study the control mechanism and molecular regulation mechanism of aging; The relationship between aging and metabolic abnormality and biological rhythm; Basic research on prevention and treatment of reproductive aging and climacteric syndrome; The relationship between aging and major diseases such as heart disease, tumor and degenerative diseases.

5. Basic research in brain science and cognitive science. Study the cellular and molecular mechanism of brain function, the occurrence and development mechanism of major brain diseases, the relationship between brain development, plasticity and human intelligence, the process and neural basis of brain advanced cognitive functions such as learning, memory and thinking, the brain information expression and processing system, and the dialogue between human brain and computer.

6. Basic research on the interaction between man and environment. Study the influence and mechanism of biological, chemical, physical and other harmful factors in the natural environment on human body, clarify the early biological effects of related factors and their relationship with the occurrence and development of diseases, study biomarkers of environmental-related diseases, and develop early warning systems for environmental-related diseases.

7. Basic research on family planning and reproductive health. Study reproduction and its regulation; Basic research on contraceptives, targeted drugs, biodegradable drug slow-release systems, anti-early pregnancy drugs and anti-early pregnancy drugs; Basic research on immune contraception; Basic research on birth defects, etc.

8. Basic research on disaster medicine. In view of natural disasters such as earthquake, typhoon, flood, traffic accident, radioactive pollution and armed conflict, the mechanism of trauma on the body and the pathophysiological response and adaptation mechanism of the body to trauma are studied. Basic research on the mechanism and prevention of psychological stress caused by disasters: basic research on emergency medical skills and equipment.

9. Basic research of traditional Chinese medicine. Carry out research on the basic theories of traditional Chinese medicine, such as Tibetan image, qi and blood, body fluid and gasification; Carry out research on the scientific connotation of authentic and medicinal properties of traditional Chinese medicine; In-depth study on the composition, ingredients, ingredients, compatibility and proportion of prescription, revealing the scientific connotation of prescription compatibility theory; Deepen the basic research of traditional classics in combination with clinical practice; Carry out research on the basic theory of meridians, the related theory of meridian function and acupuncture mechanism; Carry out basic research on TCM diseases, syndromes and prescriptions.

10. Others. Basic research on creating new drugs; Study on the mechanism and prevention of diseases caused by nutrition, obesity and lifestyle; Basic research on new methods, new technologies and new concepts related to medical health.

(3) Strengthen prevention research to reduce the risk of illness.

Carry out the strategic policy of "prevention first", comprehensively analyze the impact of biological, environmental, psychological, social and behavioral factors on health, focus on developing disease risk assessment, early screening, prediction and early warning and comprehensive intervention techniques, speed up the research on health measurement and health management, move forward the window of prevention and control of disease risk factors, realize the transformation from "preventing diseases before they occur" to "preventing diseases", and effectively reduce the risk and occurrence of diseases.

Development priorities:

1. Epidemiological study of diseases. Establish large queues of key diseases such as cardiovascular and cerebrovascular diseases, malignant tumors, metabolic diseases, mental and neurological diseases and large queues based on community population, systematically monitor the incidence and disease spectrum changes of key diseases in China, explore the causes and epidemic laws of diseases, and provide basis for disease prevention and control.

2. Study health-related risk factors and risk assessment. Focus on the health hazard monitoring and field detection technology of environmental chemical pollutants; Air and water pollution assessment technology; The impact of climate change on health hazards; Food and drug safety on-site detection and Qualcomm quantity detection methods; Detection technology of occupational hazards such as dust, radioactive substances, poisons and physical factors; Risk factors related to local high-incidence diseases.

3. Research on disease screening, prediction and early warning. Focus on strengthening the monitoring, early warning and management of chronic diseases, screening and identification of genetic susceptibility biomarkers, accelerating the development of rapid, sensitive, specific and economical disease screening, prediction and early warning technology based on Qualcomm, and improving the ability of early detection of major diseases.

4. Research on early intervention technology of diseases. Strengthen the comprehensive intervention of high-risk factors such as nutrition, environment, psychology, lifestyle and behavior, study new preventive measures, formulate and optimize tertiary prevention programs for key diseases on the basis of scientific evaluation, and promote the popularization and application of effective preventive measures in different regions.

5. Research on key technologies of family planning and prenatal and postnatal care. Strengthen the research on prevention and treatment of birth defects, comprehensively carry out research on key technologies such as identification of risk factors before pregnancy, pregnancy and infancy, risk assessment, monitoring and early warning and early intervention, and optimize and improve the overall technical scheme of three-level prevention of birth defects suitable for China population; Strengthen the research on safe, efficient and easy-to-use new contraceptive technology and new infertility prevention technology, establish a family planning technology evaluation platform, and improve the reproductive health level.

6. Health measurement and health management technology. Focus on the development of health data collection, individual health assessment, acute and chronic patient monitoring and other technologies, and carry out research on China population health indicators and commonly used test indicators, overall multi-dimensional health assessment, low-load/dynamic continuous human parameter measurement, and health status identification and control technology; Accelerate the construction of a management information system based on personal health records, and establish a national health data management system and a personal health service platform based on information technology and network technology.

7. Sub-health evaluation and intervention research. Carry out the research on the comprehensive evaluation index system of sub-health population in China, establish the reference diagnostic standard of sub-health state and classify sub-health; Study the occurrence and development law of sub-health; Comprehensive use of drug therapy and non-drug therapy, to carry out sub-health intervention strategy research, to prevent sub-health from developing into a disease state.

(4) Highlight clinical transformation and improve the level of diagnosis and treatment.

For malignant tumors, cardiovascular and cerebrovascular diseases, respiratory diseases, injuries and poisoning, digestive diseases, endocrine and metabolic diseases, genitourinary diseases, neuropsychiatric diseases, senile degenerative diseases, autoimmune diseases, hematological diseases, infectious diseases, oral diseases, otorhinolaryngology, eye diseases, skin diseases, rare diseases, etc., highlight clinical medical characteristics, give full play to the advantages of traditional Chinese medicine (ethnic medicine) in diagnosis and treatment, and optimize clinical research models. Vigorously promote the development of translational medicine, develop a number of key technologies for clinical diagnosis and treatment that are in urgent need of breakthrough, form a number of technical specifications for diagnosis and treatment on the basis of scientific evaluation, actively promote digital medical care and establish a regional medical service collaborative model, effectively solve clinical practical problems and optimize the medical service model.

Development priorities:

1. Study on new diagnosis and treatment technology. Focus on molecular diagnosis, immunodiagnosis, imaging diagnosis, biotherapy, minimally invasive treatment, interventional therapy, physical therapy and other new diagnosis and treatment technologies, innovate clinical diagnosis and treatment technologies and methods, and improve the level of clinical diagnosis and treatment technology.

2. Research on appropriate technology. Facing rural areas and communities, we will study and screen a number of safe, effective, economical and applicable health, Chinese medicine, family planning and digital medical technologies suitable for grassroots applications, establish effective popularization and application models, and improve the technical level and service capacity of grassroots medical and health institutions.

3. Research on standardized diagnosis and treatment scheme. Based on the research results of evidence-based medicine, the scientific evaluation system and method of medical technology are established, and the standardized diagnosis and treatment scheme and path are studied to provide scientific basis for classified treatment of diseases, standardize medical behavior and improve the service level of diagnosis and treatment.

4. Research on individualized diagnosis and treatment technology. Develop individualized diagnosis and treatment technology, establish molecular typing standards for key diseases, and formulate individualized diagnosis and treatment plans according to individual differences; Give full play to the traditional advantages of individualized diagnosis and treatment of traditional Chinese medicine, strengthen methodological research and clinical evaluation, and improve the ability and level of TCM syndrome differentiation and treatment.

5. Research on digital medical technology. Based on the standardization of medical information, we will focus on developing technologies such as medical information integration, electronic medical records, clinical information decision support, personal health information management and monitoring, strengthen data integration, information integration, knowledge integration and service integration, promote integrated services and regional cooperation of hospitals at different levels, optimize the allocation of medical resources and improve the level of technical services, and promote the implementation of medical reform.

6 Chinese medicine (ethnic medicine) diagnosis and treatment technology research. Strengthen the academic inheritance and experience arrangement of famous and old Chinese medicine practitioners and ethnic medicine practitioners, as well as the digital preservation and literature mining of ancient Chinese medicine (ethnic medicine) documents; Strengthen the construction of clinical evaluation system of traditional Chinese medicine, strengthen the clinical research of traditional Chinese medicine (ethnic medicine) and integrated traditional Chinese and western medicine diagnosis and treatment technology, and improve the diagnosis and treatment effect; Strengthen the research and screening of clinical appropriate technologies of traditional Chinese medicine (ethnic medicine) to promote its popularization and application.

(5) Strengthen health care and rehabilitation to serve the health of the whole people.

Focusing on the needs of medical care and rehabilitation, we will focus on breaking through the health, maintenance and psychological problems of the elderly population, improve the health level of women and children, improve the quality of life of the disabled and patients with chronic diseases, and carry out public health popularization technology research for health problems of public concern, so as to serve the improvement of the health level of the whole people.

Development priorities:

1. Health care for the elderly. Strengthen the research and promotion of the evaluation of the health status and self-care ability of the elderly, the methods and techniques for maintaining the functions of important organs of the elderly, the health monitoring and management of the elderly, the life care and nursing care of the elderly, the technical support of hospice care for the elderly, and the rehabilitation AIDS suitable for the elderly; Give full play to the advantages of traditional Chinese medicine and carry out the research of traditional Chinese medicine geriatrics.

2. Health care for women and children. Carry out monitoring research on women's reproductive health care, popularize research on prevention and treatment technologies for diseases that seriously endanger women's health, such as breast cancer, cervical cancer and reproductive system infection, and prevent and reduce common and frequently-occurring diseases among women; Strengthen the research and popularization of prevention and treatment techniques for neonatal asphyxia, pneumonia and infantile diarrhea; Strengthen the research on children's mental health; Strengthen the monitoring and intervention technology research of children's nutritional deficiency.

3. Rehabilitation of the disabled and patients with chronic diseases. Using functional compensation techniques such as exercise, vision and communication to improve the rehabilitation level of the disabled, on the basis of strengthening the treatment in acute phase and rehabilitation in control period, we will focus on strengthening the rehabilitation treatment ability of chronic diseases in recovery period, the rehabilitation mechanism of traditional Chinese medicine and the promotion of appropriate technologies.

4. Popularize public health technology. Systematically screen and sort out health knowledge and disease prevention technologies, focus on developing popularization technologies of disease prevention and control, digital communication of healthy life, and scientific and rational drug use, establish a national health website, improve the health literacy of the whole people, and realize the transformation from passive medical care to active health.

(6) Pay attention to public health and build a safety barrier.

Strengthen the prevention and control of major infectious diseases and new unexpected group diseases with unknown causes, improve the level of trauma treatment, improve the scientific and technological emergency response mechanism, enhance the medical rescue ability of public emergencies such as natural disasters, effectively deal with major public health safety issues such as food safety, occupational health and biological safety, improve the prevention and control and emergency response capabilities, and build a barrier to protect people's health and life safety.

Development priorities:

1. Prevention and control of infectious diseases. Focusing on major infectious diseases such as AIDS, viral hepatitis and tuberculosis, we will carry out research on key technologies such as detection and diagnosis, monitoring and early warning, vaccine development and clinical treatment, effectively reducing the new infection rate and mortality rate of AIDS, viral hepatitis and tuberculosis, and significantly improving the emergency response and comprehensive prevention and control capabilities of major infectious diseases; At the same time, research on the prevention and treatment of emerging infectious diseases, tropical diseases, parasitic diseases, hand, foot and mouth disease and other important infectious diseases will be carried out.

2. Medical emergency rescue. Improve the medical emergency rescue chain, strengthen technical reserves, establish an emergency medical treatment system, attach importance to psychological evaluation and intervention research of survivors after the disaster, and improve the level of emergency medical treatment and trauma treatment.

3. War trauma treatment. Carry out research on the prevention and treatment of weapon injury, war injury, field blood transfusion and training injury with military medical characteristics; Carry out research on the countermeasures of traffic accident injury treatment; Develop new first aid equipment.

4. Public health and safety. Carry out research on food safety and nutrition hygiene, environmental hazards and occupational health, biological safety, drug safety and other issues, effectively improve the level of food safety, reduce occupational hazards, reduce drug safety incidents, and ensure biological safety.

(seven) to promote the health industry and promote economic development.

Focusing on the modernization of major new drugs, medical devices and traditional Chinese medicine, we will develop strategic emerging industries of biomedicine, accelerate the cultivation of large health industries, improve the localization ability of high-end medical products, enhance the industrial scale and technological competitiveness, and provide industrial support for improving medical service capabilities while promoting economic development.

Development priorities:

1. New drug research and development. In order to meet people's basic drug demand and cultivate and develop pharmaceutical industry, we will break through a number of key technologies and production processes for drug creation, develop 30 innovative drugs, transform about 200 major drug varieties, improve the technological platform for new drug creation and modernization of traditional Chinese medicine, build a number of strategic alliances for technological innovation in pharmaceutical industry, basically form a national drug innovation system with China characteristics, and enhance the independent research and development capability and industrial competitiveness of pharmaceutical enterprises; At the same time, strengthen the clinical trial research of drugs, strengthen the monitoring of adverse drug reactions, attach importance to the development of orphan drugs and infant drugs, meet the public demand for drugs, and ensure the safety of drugs.

2. Research and development of medical devices. To study the high-end medical instruments urgently needed in China with large clinical application demand and wide application scope; Vigorously promote the development of cost-effective medical devices used by primary medical and health institutions, and improve the degree of intelligence, technical stability and product reliability; Research and development of medical device products that are easy to operate and suitable for family or individual self-care, functional rehabilitation and replacement; According to the needs of on-site rescue such as natural disasters and public health emergencies, emergency rescue equipment is developed.

3. Modernization of traditional Chinese medicine. Research on the key technologies of traditional Chinese medicine resources, quality control, efficacy evaluation, safety evaluation and adverse reaction monitoring, new preparations, clinical efficacy evaluation and production process control; Optimize and upgrade the technology of GAP planting base, carry out the cultivation of rare and endangered Chinese medicine resources and research on substitutes, strengthen the research on new Chinese medicine decoction pieces, new Chinese medicine dosage forms and new technologies, and ensure the sustainable development of Chinese medicine; Carry out the "secondary development" of traditional famous Chinese patent medicines with definite curative effect, and focus on strengthening the research and development of modern Chinese medicines with definite curative effect and relatively clear mechanism of action.

4. Develop new health products. Strengthen the research on functional food, health care products and new health care products based on TCM health care theory and diagnosis and treatment technology, and provide a number of health products to improve the public health level.

(eight) to improve the platform conditions and support the development of medicine.

According to the needs of medical science and technology development, we will systematically strengthen the construction of medical science and technology innovation system, optimize and integrate scientific and technological resources in the medical field, build key laboratories, engineering technology research centers, clinical/translational medicine research centers, medical interdisciplinary research centers, clinical collaborative research networks and other scientific and technological support systems, with reasonable layout and world-class level, and establish and improve a medical science and technology innovation system covering the whole process of basic research, applied research and development research. Promote the opening and sharing of medical science and technology resources, realize the large-scale integration of medical science and technology resources in China, promote the rapid development of medical science and technology, and lay the foundation for promoting major research achievements in the field of medical science and technology.

Development priorities:

1. New Medical Research Center. Relying on superior hospitals to build a number of clinical/translational medicine research centers, strengthen clinical medical research, promote two-way communication and interaction between basic medicine and clinical research, accelerate the transformation of cutting-edge technology and basic medical research results into clinical application, and improve the level of diagnosis and treatment technology; Relying on scientific research institutions and universities to build a number of interdisciplinary medical research centers, including systems biomedicine Research Center, Biomedical Engineering Research Center and Environmental Health Research Center. To promote interdisciplinary development and provide support for the long-term development and key breakthroughs of medical science and technology in China.

2. Clinical cooperative research network. Further strengthen the integration of domestic medical research resources, build a number of interdisciplinary and cross-regional specialist clinical collaborative research network systems based on clinical research bases, concentrate superior strength, strengthen top-level design, optimize research processes, and establish a new collaborative research and continuous promotion mechanism for major disease prevention and treatment research; Through the clinical collaborative research network system, we will systematically build a clinical sample resource database, a disease registration platform, clinical research data resources and a knowledge management center, strengthen the integration, integration, sharing, mining and analysis of medical resources and diagnosis and treatment information, and establish a China-specific disease prevention and treatment research resource group from disease occurrence, development, diagnosis and treatment to prognosis, so as to realize large-scale integration of medical research resources; Pay attention to strengthening the research platform and capacity building of medical ethics and evidence-based medicine.

3. Large cohort research base. Focus on strengthening the construction of preventive medicine research base based on community population, do a good job in overall layout and system design, build a national queue with the characteristics of resource, refinement, organization, standardization, systematization, informationization and integration, and build supporting information databases and sharing platforms to form a long-term operation mechanism.

4. Medical science and technology information and strategic research platform. Integrate information resources in the fields of medical science and life science, strengthen the construction of medical science and technology data sharing platform, strengthen the processing and in-depth analysis of medical science and technology information and the promotion of information products, and provide information support for promoting the innovation and development of medical science and technology; Strengthen research on medical science and technology strategy and health policy and management, encourage strategic research and health policy and management research in the field of medical science and technology and set up research institutions, establish an expert database of strategic research and health policy research, actively grasp the development direction and focus of medical science and technology, and improve the ability of macro-strategic planning and system design, scientific decision-making and efficient management in the medical field.

5. Medical experimental animal platform. Systematic establishment of abundant laboratory animal strain resources and laboratory animal gene mutant library; Accelerate the development of experimental mammalian models of major diseases to meet the needs of disease mechanism, drug screening and clinical treatment research; Establish a domestic model animal protection base to realize the protection and large-scale supply of experimental animals and model animals.