When was the Silk Road ever interrupted?

The Silk Road*** was interrupted twice.

The first time was at the beginning of the rise of the Arabian empire of Al-Adassi, around the time of the Tang Dynasty's Anshi Rebellion. The Tang Dynasty lost control of Central Asia because of the wars, and the Abbasids had just begun their expansionist wars and colluded with the Turfans to fight against the Tang Dynasty's sphere of influence, thus blocking the passage of the Central Asian section of the Silk Road.

The second time the Seljuk Turks rose to power, it was also the end of the Song Dynasty when the country's power declined, and the volume of trade along the Silk Road declined year by year. Until the beginning of the Yuan Dynasty, the Mongols mass slaughter of Central Asian countries, resulting in thousands of miles of no man's land. The Silk Road was interrupted for a time until the period of Emperor Chengzu of the Ming Dynasty before it was restored.