What are the unified standard chemotherapy regimens for tuberculosis?

In order to give full play to the role of chemotherapy in the prevention and treatment of tuberculosis, to facilitate the development of chemotherapy on a large scale, and to solve the practical problems of poor therapeutic efficacy, high cost, excessively short or long treatment period, and wastage of drugs and resources caused by the abuse of anti-tuberculosis drugs, irrationality and confusion of chemotherapy regimens, a standardized chemotherapy regimen can be chosen as a unified standard regimen, under conditions such as the therapeutic efficacy of chemotherapy regimens, adverse effects, treatment costs, acceptance by the patients, and the availability of drugs. Under comprehensive consideration of the efficacy, adverse effects, treatment cost, patient acceptability and drug supply of the chemotherapy regimen, the chemotherapy regimen that has been confirmed by strict controlled studies at home and abroad can be chosen as the unified standard regimen. Practice has confirmed that the strict implementation of the unified standard program can achieve the expected results, in line with the principle of input efficiency.

1. The first treatment of smear-positive pulmonary tuberculosis treatment program includes the first treatment of smear-negative cavity formation or millet-type tuberculosis.

(1) Daily medication regimen: ① consolidation period: isoniazid, rifampicin, pyrazinamide and ethambutol, taken at once, 2 months. ②Consolidation period: isoniazid, rifampicin, at once, for 4 months.

Shortened to 2HRZE/4HR.

(2) Intermittent regimen: (1) Intensive phase: isoniazid, rifampicin, pyrazinamide, and ethambutol, every other day or three times a week for two months. Consolidation period: isoniazid, rifampicin, every other day or 3 times a week for 4 months. Abbreviation: 2H3R3Z3E3/4H3R3.

2. Treatment regimen for retreatment of smear-positive TB

(1) Daily regimen: ① Intensive phase: isoniazid, rifampicin, pyrazinamide, streptomycin, and ethambutol, once a day for 2 months. (2) Consolidation period: isoniazid, rifampicin and ethambutol once daily for 4 to 6 months. If sputum is not negative at the end of the 4-month consolidation period, the treatment period can be extended for another 2 months. Abbreviation: 2HRZSE /4-6HRE.

(2) Intermittent drug regimen: (1) Intensive phase: isoniazid, rifampicin, pyrazinamide, streptomycin, and ethambutol, every other day or three times a week for two months. Consolidation: isoniazid, rifampicin, and ethambutol, every other day or 3 times a week for 6 months. Abbreviations:

2H3R3Z3S3E3/6H3R3E3.

3. Primary smear-negative TB regimen

(1) Daily regimen: (1) Intensive phase: isoniazid, rifampicin, and pyrazinamide once daily for 2 months. (2) Consolidation period: isoniazid, rifampicin, once daily for 4 months.

Short form: 2HRZ/4HR.

(2) Intermittent medication regimen: (1) Intensive phase: isoniazid, rifampicin, pyrazinamide, every other day or 3 times a week for 2 months. ② consolidation period: isoniazid, rifampicin, every other day or three times a week, 4 months. The abbreviation is 2H3R3Z3/4H3R3.

The above intermittent regimen is used for TB planning in China, but it is necessary to use the whole supervised chemotherapy management to ensure that the patients take the medication regularly without interruption.