Mice born dead after gene knockout, what are the causes?

Death at birth in mice born after a gene knockout may be caused by a disorder of gene sequencing.

Knockouts are generally applied to mice, and the most commonly used mouse line is 129 and its heterozygotes because these mice have a tendency to spontaneously mutate to form teratomas and teratosarcomas, which make them ideal experimental animals for knockouts. Whereas embryonic stem cell lines from other genetic backgrounds are gradually being developed for application, the most embryonic stem cell line from C57BL/6×CBN/JNCrjF1 mice was successfully used for gene knockout.

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