Significance of pharmacological research of traditional Chinese medicine to modernization of traditional Chinese medicine

Modernization of traditional Chinese medicine is a process of combining the advantages and characteristics of traditional Chinese medicine with modern science and technology to meet the needs of contemporary social development. The key to the modernization of traditional Chinese medicine is to change the concept. That is, the modernization of academic guiding ideology. Pharmacological research of traditional Chinese medicine is not a simple combination of "traditional Chinese medicine" and "pharmacology". Pharmacological research of traditional Chinese medicine should be based on the basic theory of traditional Chinese medicine to avoid westernization of traditional Chinese medicine. The use of traditional Chinese medicine is guided by the theory of traditional Chinese medicine, but the theory of traditional Chinese medicine has not found strong evidence, which makes traditional Chinese medicine fall into the same situation, that is, on the one hand, it affirms the clinical efficacy of diseases, on the other hand, it lacks strong scientific data to prove it, which makes its use mostly limited to experience. Traditional Chinese medicine has four qi and five flavors, ups and downs. Meridian tropism, reinforcing diarrhea, clearing heat, warming interior, benefiting qi, etc. Can be used for treating patients' syndrome; Western medicine has a clear chemical composition, and its configuration and physical and chemical properties determine its curative effect, which is used to treat local diseases. At present, the so-called pharmacological research of traditional Chinese medicine is essentially copying the pharmacological research methods of modern western medicine. The author thinks that the real pharmacological research of traditional Chinese medicine should make a breakthrough in the understanding of traditional Chinese medicine theory and traditional four-qi and five-flavor theory. The guiding ideology and technical means of pharmacological research of traditional Chinese medicine must have new ideas and breakthroughs.

Pharmacology of Traditional Chinese Medicine Through the pharmacological study of traditional Chinese medicine, it is necessary to reveal the essence of four qi and five flavors, ups and downs and meridian tropism of traditional Chinese medicine one by one. Proceeding from the clinical practice, the pharmacological research of traditional Chinese medicine should focus on prescriptions and take holistic research as the main research method to establish a large number of scientific and reasonable animal models of diseases (syndromes) of traditional Chinese medicine. Experimental methods, observation indicators, result analysis, evaluation criteria, etc. That is, the pharmacological method completely conforms to the characteristics of traditional Chinese medicine. On this basis, the research on serum pharmacology, compound pharmacokinetics, serum pharmacochemistry and compound chemistry of traditional Chinese medicine was improved and perfected. At the same time, we will actively carry out pharmacological research on molecular pharmacology, quantum pharmacology and receptor pharmacology of traditional Chinese medicine, as well as pharmacological research on ion channels, enzymes and genes, combine the whole with high-level experiments, analysis and synthesis, and combine traditional Chinese and western medicine to comprehensively and deeply explain the therapeutic effects of traditional Chinese medicine from various aspects and levels. At present, Chinese scholars have made some progress in the substantive research of TCM "syndrome".

Pharmacology of traditional Chinese medicine, as an applied discipline, plays an irreplaceable role in the development, research and production of new Chinese medicine. In the process of research on new Chinese medicine, pharmacodynamics and toxicology research has always been regarded as a statutory necessary research project. One of the basic tasks of the modernization of traditional Chinese medicine is to develop Chinese traditional medicine products with independent intellectual property rights, which can be in line with the international pharmaceutical market. Its positioning must be "safe, efficient, high-quality, stable and controllable", in which safety and effectiveness are the most important characteristics of drugs. Efficacy evaluation is completed by the subject of pharmacology of traditional Chinese medicine. China's current Drug Administration Law stipulates that any traditional Chinese medicine preparation must undergo strict efficacy and safety evaluation tests before entering clinical trials. It can be seen that pharmacology of traditional Chinese medicine will play a very important role in both the basic theoretical research of traditional Chinese medicine and the modernization research of traditional Chinese medicine. It is imperative to strengthen the basic research on pharmacology of traditional Chinese medicine. Explaining the metabolic process, pharmacological action and mechanism of traditional Chinese medicine in vivo with scientific language has potential social significance and economic value for the modernization of traditional Chinese medicine and the international market.