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In fact, the reason is very simple, and there is only one:

Laboratory bacterial resistance determination is generally used in the paper sheet method, but this method only detects the antibacterial effect in vitro, and can not reflect the body, the drug enters the human body after the changes in the human body is very complex, the laboratory method can not completely simulate the situation of the drug in the body, and the emergence of a great discrepancy is also completely possible. The laboratory methods do not fully simulate the drug in the organism, and great variation is entirely possible. If you use animal testing to detect drug resistance, it is relatively good, but animal testing is too complicated, and the operation is cumbersome, and the influence of factors are diverse.