What are the advantages of parenteral nutrition fat emulsion?

Advantages of parenteral nutrition preparation fat emulsion: many drugs in clinic have poor water solubility and must rely on solvents to play their role. However, organic solvents are not only toxic, but also may interfere with the efficacy. Fat emulsion with soybean oil as the main component has solvent characteristics and almost no toxicity. Some drugs, using fat emulsion as solvent, reduce the occurrence of drug-related complications and effectively control the release of drugs. Dexamethasone, diazepam and short-acting anesthetic (propofol) are commonly used carrier solvents in clinic. It was found that the addition of amphotericin B to fat emulsion has less toxic and side effects on the body than the addition of 5% glucose solution, and the clearance rate in the body is also accelerated [6]. It is believed that in the near future, fat emulsions will be more and more used in drug carrier systems.

Fat emulsion, also known as fat emulsion, fat emulsion and fat emulsion injection, is a white milky liquid. It is suitable for patients who need high calories (such as malignant diseases such as tumors), patients with renal damage, patients who are forbidden to take protein, and patients who cannot take nutrition through the gastrointestinal tract for some reason, so as to supplement appropriate calories and essential fatty acids. Its components are soybean oil, lecithin, glycerol and water for injection.

Fat emulsion is a parenteral nutrition agent, which provides calories and essential fatty acids for nutrition, without the shortcomings of high osmotic pressure of amino acids and sugar solutions. After entering the blood, it combines with apolipoprotein C in the blood. Under the action of lipoprotein lipase, triacylglycerol is decomposed into non-esterified fatty acids, which provide energy and essential fatty acids for the body. Non-esterified fatty acids can also be combined with albumin in plasma, or oxidized by liver, converted into very low density lipoprotein, and then enter the blood stream. Its particle size is similar to that of natural chyle particles, and they are all metabolized through the same metabolic pathway.

Composition and metabolic characteristics of fat emulsion

Fat emulsion is an oil-in-water emulsion, which is mainly composed of vegetable oil, emulsion and isotonic agent. Fat emulsion has high energy density, and provides high heat with small capacity, and 1 g of fat can provide 37.62 kilojoules (kJ) after oxidation. The significance of clinical application of fat emulsion lies in providing

However, the entry of LCT into mitochondrial metabolism depends on the transport of carnitine, and the rate of oxidative metabolism is slow. Some studies have found that it may accumulate in reticuloendothelial cells for a long time, and there may be lipochromatosis in liver and spleen.