Classic Chinese patent medicine

The clinical manifestations of atherosclerosis are varied and the causes are complex, but the most fundamental reasons are blood and vascular endothelium, blood stasis, adhesion, platelet aggregation, high cholesterol, high triglyceride and vascular endothelial injury.

In recent years, clinical practice has proved that Chinese patent medicines for promoting blood circulation and removing blood stasis have achieved satisfactory results in anti-atherosclerosis. The combination of traditional Chinese and western medicine has complementary advantages, which is more favorable than single western medicine or traditional Chinese medicine in treating this disease. It can improve clinical symptoms and reduce morbidity and mortality, among which Musk Baoxin Pill and Xiao Su Jiuxin Pill are typical representatives.

Shexiang Baoxin Pill is composed of seven herbs: musk, ginseng, bezoar, borneol, storax, cinnamon and toad venom. It has the effects of fragrant warming heart, benefiting qi and strengthening heart. Shexiang Baoxin Pill has many effects on cardiovascular system, among which the anti-atherosclerosis effect is important, which can reduce blood lipid, alleviate inflammatory reaction, obviously inhibit intima-media hyperplasia, reduce intima-media thickness and reduce plaque area, and is suitable for patients with qi stagnation and blood stasis syndrome.

Modern pharmacological research shows that Shexiang Baoxin Pill contains many chemical components, including two bile acids, one is ursodeoxycholic acid and the other is chenodeoxycholic acid, which can inhibit the production of cholesterol and treat hypertriglyceridemia. After treatment, the total cholesterol, triglyceride and low-density lipoprotein cholesterol of patients can be significantly reduced. Its mechanism may be to accelerate the clearance of cholesterol, promote the reverse transport of cholesterol in cells, reduce the accumulation of foam cells in atherosclerotic plaques, and reduce the oxidative damage of excessive lipoprotein in blood circulation to endothelial cells, thus playing an anti-atherosclerosis role.

Studies have shown that Shexiang Baoxin Pill can inhibit the development of atherosclerosis by inhibiting mitochondrial-dependent apoptosis of endothelial cells, scavenging reactive oxygen species. Autophagy is a conservative evolutionary process, which degrades and recovers intracellular substances through lysosomal pathway, thus actively coping with the stress state of cells to maintain steady state. Autophagy defect or impaired autophagy ability will reduce the ability of cell clearance and cause stress, oxidation and inflammatory reactions, so it is closely related to the occurrence and development of atherosclerosis. Shexiang Baoxin Pill can also inhibit the development of atherosclerotic plaque by activating autophagy.

To sum up, Shexiang Baoxin Pill can inhibit the development of atherosclerotic plaque and has anti-atherosclerosis effect, and its mechanism may be related to inhibiting inflammatory reaction, increasing plaque stability, promoting cholesterol clearance and reverse transport, and activating autophagy.

Xiao Su Jiuxin Pill is composed of Ligusticum Chuanxiong and Borneolum Syntheticum. It has the effects of promoting qi circulation, promoting blood circulation, removing blood stasis, relieving pain, improving symptoms of patients with coronary heart disease and angina pectoris, resisting myocardial ischemia, improving electrocardiogram and inhibiting atherosclerotic plaque formation, and is suitable for patients with qi stagnation and blood stasis syndrome.

At present, Xiao Su Jiuxin Pill is mainly used for acute attack of angina pectoris, prevention and long-term treatment of angina pectoris, acute coronary syndrome and perioperative treatment. Modern pharmacological research shows that Xiao Su Jiuxin Pill has the functions of anti-atherosclerosis, protecting vascular endothelial function, inhibiting platelet aggregation and thrombosis, relaxing blood vessels, improving blood circulation and preventing myocardial ischemia-reperfusion injury.

The anti-atherosclerosis mechanism of Xiao Su Jiuxin Pill mainly plays a role by regulating the blood lipid of patients with atherosclerosis, obviously lowering blood cholesterol, triglyceride and low-density lipoprotein cholesterol, lowering blood viscosity, lowering platelet activity, improving hemorheology and microcirculation. The results showed that 4-6 quick-acting Jiuxin pills were taken orally three times a day, and the effect was satisfactory. In the Expert Knowledge of Diagnosis and Treatment of Atherosclerosis with Integrated Traditional Chinese and Western Medicine published by Cardiovascular Disease Committee of China Association of Integrated Traditional Chinese and Western Medicine on 20 17, it is recommended that Xiao Su Jiuxin Pill can be used to treat patients with atherosclerosis.

In short, classic Chinese patent medicines have many functions in improving cardiovascular diseases, such as Shexiang Baoxin Pill and Suxiao Jiuxin Pill, which are not only used for acute attack of angina pectoris of coronary heart disease, but also have outstanding anti-atherosclerosis effects, especially suitable for patients with coronary heart disease complicated with atherosclerosis, which can not only eliminate symptoms, but also improve the problem of atherosclerosis from the root.