What is the efficacy and function of Sophora flavescens?

Sophora flavescens is distributed all over China, and the medicinal part is the dried roots of plants. It contains matrine, oxymatrine, matrine, etc. , can enhance human immunity, anti-allergic, is a commonly used Chinese herbal medicine in clinic.

1. antiasthmatic expectorant

Matrine can relieve bronchospasm and inhibit the release of antibodies and slow-acting substances by exciting β receptors, especially β receptors in the excitation center, thus producing antiasthmatic effect.

Calm your nerves.

The total alkaloids of Sophora flavescens can significantly enhance its central inhibitory effect, and can also significantly resist the psychomotor excitement caused by central stimulants amphetamine (intraperitoneal injection, 4-6mg/kg) and caffeine (50mg/kg). The total alkaloids of Sophora flavescens have mild analgesic effect when used alone, and the percentage of analgesia can be significantly increased when combined with threshold dose morphine. It can be used for mild anesthesia in clinic.

Treat inflammation

The TCM syndrome differentiation of chronic hepatitis B includes damp-heat and blood stasis, liver depression and qi stagnation, deficiency of both liver and spleen, etc. Matrine is an important drug for the treatment of hepatitis, which is extracted from Sophora Tonkinensis and contains derivatives of matrine. Sophora flavescens decoction can treat hepatitis and reduce transaminase. HBsAg and HBeAg turned negative, and HBV-DNA titer decreased, which is an important traditional Chinese medicine.

Treat dysentery

Bacillary dysentery and amebic dysentery are characterized by damp-heat accumulation in traditional Chinese medicine. There are many Chinese medicines for clearing damp-heat in intestines, such as Coptidis Rhizoma, Cortex Phellodendri, Radix et Rhizoma Rhei, Pulsatilla, Cortex Fraxini and so on. However, Sophora flavescens is the most effective drug to treat dysentery, and the main treatment is to clear damp-heat and induce common diseases. Sophora flavescens is mainly used in the treatment of dysentery in Chinese medicine.

5. disgust

Sophora flavescens contains matrine, and both matrine and oxymatrine can inhibit the immune function of mice at the dose of 1/5LD50. Intramuscular injection of oxymatrine (150mg/kg or 100mg/kg) in rabbits and rats has obvious inhibitory effect on passive or active skin allergic reaction and the formation of IgE antibody in rabbit serum.

Intraperitoneal injection of oxymatrine (200 mg/kg d, ***2 1 day) has protective effect on the death caused by immediate allergic reaction in mice. It can be seen that Sophora flavescens has a certain effect on allergic reaction caused by immune excess of autoimmune system, and can be used to prevent and treat allergies.

6. Anti-tumor

Matrine can inhibit Ehrlich ascites carcinoma and sarcoma in mice in vitro and in vivo-180.

Extended data:

Nutritional value of Sophora flavescens

Sophora flavescens contains many alkaloids and flavonoids, such as matrine, oxymatrine, N- oxysophoridine, sophoridine, d- isomatrine, L- sophoridine, flavanone, flavanone, etc.

1, ethyl ether extract and ethanol extract of Sophora flavescens have strong antibacterial effects on Staphylococcus aureus; The aqueous solution of Sophora flavescens has inhibitory effects on Trichophyton purpurea, Trichophyton concentric, Trichophyton xulan and Microsporum Odon.

2. Matrine can inhibit Ehrlich ascites carcinoma and sarcoma in mice in vitro and in vivo-180.

3. Sophora flavescens total alkaloids and oxymatrine have obvious whitening effect, and have obvious therapeutic effect on leukopenia caused by cyclophosphamide, X-ray and cobalt ray irradiation.

4. Matrine can inhibit auricle swelling in mice caused by croton oil, abdominal exudation in mice caused by acetic acid and foot pad swelling in rats caused by carrageenan.

Source of reference: China Health Network-efficacy and function, contraindications and eating methods of Sophora flavescens.