The commonly used controls in clinical research are single-blind, double-blind and triple-blind.

The commonly used controls in clinical research are single blind, double blind and triple blind open.

Extended data:

In clinical research, control is a commonly used research design method. By comparison, researchers and participants can better understand and study the effects of some intervention measures (such as drugs, treatments, etc.). ). Comparative studies mainly include single blind, double blind, triple blind and open.

1. Blind plate with single ring

Blindness means that one party (usually the subject) in the study does not know whether he has accepted the experimental intervention. This design method can reduce the influence of psychological factors on the research results. However, the single-blind design also has limitations, because researchers may produce deviations in the process of collecting and analyzing data.

2. Double blind

Double-blind means that the subjects and researchers in the study don't know which subjects have received experimental intervention. This design method can effectively reduce the influence of psychological factors of researchers and subjects on the research results. Double-blind design is a common control method in clinical research, especially in drug trials. Through double-blind design, researchers can evaluate the effect of intervention measures more objectively and are not affected by subjective prejudice.

3. Three blindness

Three blindness refers to blind processing of data analysis on the basis of double-blind design. In other words, the data analyst doesn't know which subjects received the experimental intervention. The triple blind design can further reduce the deviation in the research process and improve the reliability and accuracy of the research. However, the three-blind design is more complicated and expensive in practice, so not all clinical studies will adopt it.

Step 4 open the label

Open design means that both the subjects and researchers in the study know which subjects have received experimental intervention. This design method is suitable for those studies with obvious intervention measures and not easily influenced by psychological factors. The main advantage of open design is that subjects and researchers can understand the effect of intervention measures more clearly. However, open design may also lead to errors in data collection and analysis.

Summary:

The commonly used control methods in clinical research are single blind, double blind, triple blind and open. All kinds of control methods have their advantages and disadvantages, and researchers need to choose the appropriate control method according to the actual research purpose, the characteristics of intervention measures and research resources.

In practice, double-blind design is the most commonly used control method, because it can effectively reduce the psychological factors of researchers and subjects on the research results. However, for some special types of research, other control methods may be more suitable. When choosing control methods, researchers should fully consider the rationality, feasibility and effectiveness of the research design.