What is the function and function of madder?

1, stop bleeding:

Rabbits can obviously promote blood coagulation within 2-4 hours after taking an appropriate amount of madder extract orally or 30-60 minutes after intraperitoneal injection of the same amount of madder extract.

The results show that the calcium recovery time, prothrombin time and partial thromboplastin time on white clay are shortened. Oral madder charcoal can also significantly shorten the tail bleeding time of mice. Madder can also obviously correct the coagulation disorder caused by heparin.

2. Anti-platelet aggregation:

Swertiamarin has a strong inhibitory effect on rabbit platelet aggregation induced by arachidonic acid and collagen in vitro, and also has a certain inhibitory effect on platelet activating factor. It can strongly inhibit platelet aggregation induced by collagen.

3, increase the role of white blood cells:

The crude extract of madder has the effect of increasing white blood cells. One of its effective components for increasing white blood cells is phenolic carboxylic acid glycoside with aromatic ring, and the derivative of this effective component, rubioxalate, is artificially synthesized.

Alizarin diester can also promote the proliferation and differentiation of mouse bone marrow hematopoietic stem cells and prevent and treat canine leukopenia caused by cyclophosphamide.

4, antitussive and expectorant effects:

The methods of inducing cough with ammonia water and excreting phenol red showed that Radix Rubiae decoction had obvious antitussive and expectorant effects on mice, but alcohol precipitation filtrate was ineffective.

5, antibacterial effect:

In vitro experiments showed that the aqueous extract of Radix Rubiae had certain inhibitory effects on Staphylococcus aureus, Streptococcus pneumoniae, Influenza Bacillus and some skin fungi, and adriamycin also had inhibitory effects on Staphylococcus aureus.

6, anti-cancer effect:

The intraperitoneal injection of cyclohexyl peptide compounds contained in Radix Rubiae for 5 consecutive days has a significant effect on mouse lymphoblastic leukemia P388. It has obvious activity on mouse lymphoblastic leukemia, breast cancer, melanoma, colon adenocarcinoma, lung cancer and Ehrlich cancer.

7, the role of urinary calculi:

Feeding madder preparation to mice can prevent the formation of experimental kidney calculi and bladder stones, especially inhibit the formation of calcium carbonate stones. The intake of madder root extract in rats can obviously improve the stability of urine, reduce the risk of urolithiasis and reduce urinary calcium to some extent.

8. Therapeutic effect on experimental myocardial infarction:

Continuous ligation of left anterior descending coronary artery leads to artificial myocardial infarction model. Intravenous injection of madder extract separated by different methods can reduce the elevation of S-T segment and narrow the range of myocardial infarction.

The water-soluble part of madder extract injected intraperitoneally into mice can obviously increase the ATP content in myocardium and brain tissue, and has depolymerization effect on ADP-induced platelet aggregation in rats. It can protect acute myocardial ischemia under anesthesia, reduce the scope and degree of myocardial injury and increase coronary artery flow.

9. Effect on smooth muscle:

Qiancao decoction can resist the intestinal spasm caused by acetylcholine in isolated rabbits and has spasmolytic effect. The water extract of root has exciting effect on isolated guinea pig uterus.

10. Other functions:

The warm extract of madder root can dilate the blood vessels of frogs. Alizarin, similar to rutin, can inhibit the permeability of connective tissue in rat skin.

References:

Baidu encyclopedia-madder