[Medicinal value of marine life] The medicinal significance of marine life

Marine life refers to all kinds of life in the ocean, including marine animals, marine plants, microorganisms and viruses, among which marine animals include invertebrates and vertebrates. Invertebrates include various snails and shellfish. Vertebrates include various fishes and large marine animals, such as whales and sharks.

Marine life is rich in digestible protein and amino acids. The nutritional value of food protein mainly depends on the composition of amino acids. Marine organisms such as fish, shellfish, shrimp and crab are rich in protein, which is rich in nine kinds of amino acids necessary for human body, especially lysine, which is much higher than plant food and is easily absorbed by human body.

According to experts, the ocean is an important source of natural medicines. According to the records in Erya and Huangdi Neijing, it can be inferred that as early as 65438 BC+0027 BC to 300 BC, marine drugs have been used in medical practice. There are records of marine drugs in Shenlong Materia Medica Classic, Haiyao Materia Medica, Compendium of Materia Medica and Compendium of Materia Medica. The Dictionary of Traditional Chinese Medicine contains 144 kinds of marine drugs. Marine drugs have a long history, so it is extremely necessary to study and develop them with modern science and technology for rich marine resources. At present, there are 22 kinds of single drugs made from marine organisms in China, and there are 152 kinds of compound Chinese patent medicines made from marine organisms and other drugs. These drugs combine traditional Chinese medicine theory with modern medicine and high technology, and play an important role in clinic.

Study on marine polysaccharide drugs for treating gastric ulcer

Project Description: This project takes marine biological polysaccharide as the basic raw material, and after structural modification, develops a new type of marine drug for treating gastric ulcer, which can quickly promote wound healing of gastric ulcer, stop bleeding, relieve pain, and buffer the stimulation of gastric acid on the wound surface, without toxic side effects. Pharmacodynamic studies show that the polysaccharide has a good effect of promoting wound healing of gastric ulcer and killing Helicobacter pylori, and its curative effect is better than famotidine, Dele and Denotel, and it has the characteristics of less dosage and less side effects. The project has passed the expert appraisal organized by the Science and Technology Department of Shandong Province, and the technical level of research results has reached the international leading level. The main research contents of this project include: production technology, chemical composition and structure, quality standards, stability, pharmacodynamics and toxicology of raw materials and preparations. , and has completed the preclinical research content.

Marine biological burn ointment

Project Description: This project is a scientific and technological key project "Anti-ulcer Marine Drugs" undertaken by the Marine Bioactive Substances Laboratory of China Ocean University. The effective components for promoting the healing of burns and ulcers and inhibiting the growth of scars were extracted from marine organisms, and a "marine biological burn ointment" was developed through a unique production process. The marine medicine has the advantages of promoting wound healing, relieving pain, diminishing inflammation and leaving no scar after treatment. It is superior to the drugs such as Jingwanhong currently used in clinic, which is not only suitable for clinical use, but also can be used as a family standing drug. The production of the main effective components of marine biological burn ointment has been authorized by the national invention patent, so the development of this medicine has independent intellectual property rights. The main research contents of this project include: production technology, chemical composition and structure, quality standard, stability, pharmacodynamics and toxicology of raw materials and preparations.

Study on marine polysaccharide drugs for treating gastric ulcer

Project Description: This project takes marine biological polysaccharide as the basic raw material, and after structural modification, develops a new type of marine drug for treating gastric ulcer, which can quickly promote wound healing of gastric ulcer, stop bleeding, relieve pain, and buffer the stimulation of gastric acid on the wound surface, without toxic side effects. Pharmacodynamic studies show that the polysaccharide has a good effect of promoting wound healing of gastric ulcer and killing Helicobacter pylori, and its curative effect is better than famotidine, Dele and Denotel, and it has the characteristics of less dosage and less side effects. The project has passed the expert appraisal organized by the Science and Technology Department of Shandong Province, and the technical level of research results has reached the international leading level. The main research contents of this project include: production technology, chemical composition and structure, quality standards, stability, pharmacodynamics and toxicology of raw materials and preparations. , and has completed the preclinical research content.

Micro-health agent

Project Description: This product is made of various marine organisms and refined by biochemical technology. It is rich in amino acids, aminoethanesulfonic acid, vitamins, unsaturated fatty acids and rich and suitable trace elements such as iodine, zinc, potassium and calcium. Has dual effects of nutrition and health care, and can prevent iodine deficiency disorders and cardiovascular diseases, protect myocardium and liver, promote brain development of newborns and children, protect eyesight and improve immunity.

Product Development of "Ocean Bird's Nest"

Project Description: "Ocean Bird's Nest" is an advanced nutritional tonic. Regular drinking can continuously supplement the nutrients needed by the human body. Especially for middle-aged and elderly people or patients, it can not only supplement nutrition, but also enhance the immunity of the body, especially for the prevention and treatment of gastrointestinal diseases and the beauty effect on the human body. This product is rich in nutrition and has good health care function, such as protein, peptides, polysaccharides and other substances, as well as various inorganic elements and trace elements.

Research and Development of Medicinal Functional Genes of Marine Organisms

Overview of the project: This project systematically studies and develops the functional genes of medicinal marine organisms in China by using biotechnology such as efficient functional expression cloning, bioinformatics, large-scale functional screening and large-scale sequencing, and establishes a set of research system and technical platform for large-scale medicinal functional genes of marine organisms, providing a number of innovative functional genes and domestic and foreign patents (PCT) with important medicinal value for Chinese medicine and other related fields, strategically providing reliable technical support and theoretical basis for the sustainable utilization and development of rich medicinal marine biological resources in China, and further developing them. Project * * * has constructed 26 high-quality cDNA libraries of medicinal marine tissues. By using bioinformatics technology and rapid screening of functional genes, 97 functional genes with application prospects have been preliminarily identified, and 15 functional genes have been systematically studied.

Marine biological protease

Project Overview: The technical achievement of this project is mainly to produce a new type of marine biological protease through fermentation, and then develop three leading products, which are applied in daily chemical and light industry fields. A new species of Flavobacterium with independent intellectual property rights in China, a new low-temperature alkaline protease and its genes were discovered, and the invention patent of "a new low-temperature alkaline protease and its manufacturing method, application and microorganism producing the protease" was obtained. Compared with traditional protease, this protease has the unique advantages of low temperature resistance, oxidation resistance and good compatibility with complex reagents, which is more suitable for the requirements of modern industrial production.

Brief introduction of marine biological insecticide JMT

Project outline: JMT is a new biological pesticide extracted from marine organisms and developed through deep processing. A large number of studies and experiments show that JMT insecticide has high activity on pear net stinkbug, the mortality rate can reach more than 97% within 48 hours, and the semi-lethal concentration LC50 is 1 14μ g/ml. It also has strong insecticidal activity against Spiraea aphis, Myzus persicae, Aphis Medicago, Plutella xylostella and Pieris rapae. Toxicological tests showed that the oral LD50 of JMT in male and female rats was greater than 4640 mg/kg. The percutaneous LD50 of male and female rats is greater than 2 1.50 mg/kg. No irritation to rabbit skin and eyes. According to the classification standard of acute toxicity of pesticides in China, JMT belongs to low toxicity pesticides.

Research and resource utilization of new bioactive substances from marine organisms

Project Description: In this study, the marine life in various sea areas of China was extensively investigated and samples were collected. The chemical constituents and biological activities of 23 marine organisms were systematically studied by screening the activity of Magnaporthe grisea model and cytotoxicity model. It was found that the new compound, Ferulide A, isolated from Acanthopanax squamosa, has a significant inhibitory effect on tumor angiogenesis, and it is a new tumor angiogenesis inhibitor. After structural modification, 14 new derivatives were obtained. After screening for antitumor activity, it was found that CU302 derivatives had better antitumor activity and reduced toxicity. It can obviously inhibit the proliferation of endothelial cells HMEC- 1, inhibit the migration, lumen formation and angiogenesis of chick embryo allantoic membrane, and induce endothelial cell apoptosis. It also showed strong cytotoxic activity against 14 human tumor cell line, and had dual anti-tumor effects.

Marine biological quality standard

Project Description: The establishment of marine biological quality standard is an environmental quality standard based on a large number of scientific investigation and experimental research data, using marine biological and ecological indicators, and combining the actual situation and scientific research in China. The project studies and establishes marine biological standards to reflect the impact of pollution on marine life, evaluate the quality of marine environment, and apply these standards to evaluate the harm of pollution to ecosystems and biological resources. The formulation of this standard is of great significance to Marine pollution detection, marine environmental protection and human health protection. Reached the international level and won the second prize of marine innovation achievements of the State Oceanic Administration. Marine Biological Quality (GB 1 8421-2001) was implemented on March/October, 2002, which is in line with seawater quality standards and other environmental standards, and constitutes the legislative system of marine environmental quality standards in China. The formulation of standards provides a scientific legal basis for the monitoring and prevention of marine pollution, and plays an important and positive role in strengthening marine management, scientifically and rationally utilizing marine resources and promoting the sustained and healthy development of China's marine economy.

Natural marine biological health food for improve sleep

Project Description: This health food takes Poria cocos, kelp and jujube as the main raw materials, absorbs the relevant experience and essence of traditional Chinese medicine, applies the separation and extraction method at the molecular level, and combines with the directional interception technology of specific biological enzymes in modern bioengineering to develop a polysaccharide that can take effect quickly and make brain cells quickly return to normal sleep function. The product is safe, has no toxic and side effects, and does not produce dependence and addiction. Suitable for all kinds of people with poor sleep.

Research and Development of Marine Biological Product "Sea Elf" for Anti-rheumatoid Arthritis

Project Description: This product is composed of a variety of marine bioactive substances, and its technical key is to creatively utilize the synergistic effect of a variety of natural active ingredients that can effectively dredge the human circulatory system, resist oxidation, improve immune activity and promote bone cell metabolism, so as to relieve arthritis symptoms and even completely cure arthritis. This project combines the mode and principle of AIDS cocktail therapy with traditional Chinese medicine compatibility, and uses high technology to extract a variety of natural products from marine organisms that can inhibit or control joint tissue lesions, and organically synthesize anti-rheumatoid arthritis products with remarkable effects.

Nongle 2, a special marine biological preparation for tobacco.

With marine polysaccharide as the main component, the special marine biological preparation "Nongle No.2" for tobacco was developed. It has a variety of active functions, and can play a synergistic role in promoting growth, improving quality, sterilizing and resisting virus. After using "Nongle No.2", the yield per mu increased by 8.2 ~ 9. 1%, the output value increased by1.2 ~ 21.2%, and the proportion of excellent tobacco increased by 4.3 ~ 33.8%. At the same time, it has obvious disease resistance and bacteriostasis, the inhibition rate of tobacco brown spot disease can reach 82%, the disease index can be reduced by 40%, and the control effect of tobacco mosaic virus disease can reach 85.7%. It is a new tobacco biological preparation with low cost (only 5 ~ 6 yuan per mu), non-toxic, harmless and pollution-free. The experimental area is 5000 mu, and more than 20000 mu is popularized. Established a pilot plant with an annual output of 500 tons. In the future, the varieties of experimental crops will be further increased and the extension area will be expanded. The successful development of this product has laid a foundation for the application of rich marine biological resources in agriculture in China, which has important scientific significance and application prospects.

Development of marine biological functional food

Project Overview: This project uses rich marine life (a kind of Syngnathidae) to develop functional health food with anti-fatigue and anti-aging effects. The marine organism has sex hormone-like effect, anti-aging and anti-tumor activity, and a new preparation process is adopted to develop health food suitable for middle-aged and elderly people. The project has completed process design, function test and quality standard. According to the requirements of functional food declaration, it is expected that all application materials will be completed before the end of June 2008. The project is characterized by the development and utilization of rich marine fish resources; Develop functional food with strong efficacy and low price from marine life; This is the first one in China.

New technology for industrial production of oligochitosan and chitooligosaccharides, marine bioactive substances

Project Overview: This project studied and improved the technological conditions of enzymatic hydrolysis, separation and drying of chitosan, and established a new technology for industrial production of low-chitosan and chitosan oligosaccharide. This research work has not been reported in patents and literatures at home and abroad, and it has obvious technical advantages, distinctive characteristics and innovation, reaching the international advanced level, and has the ability to replace domestic low-shell sugar and chitosan oligosaccharide in quality and price to meet the requirements of the international market. The industrial production of 100 tons/year low-shell sugar and 10 tons/year chitosan oligosaccharide can be realized.

Enzymatic production technology of chitin and development of its deep-processed products

Project outline: This project mainly studies the application effect of chitin/chitosan and its derivative chitooligosaccharides extracted from marine organisms in livestock and poultry breeding and health care. This product is a potential functional green feed additive. Because it has the functions of no drug resistance, no drug residue, promoting growth and improving survival rate, it can be widely used in livestock and poultry feed, aquatic feed, especially export-oriented enterprise feed, and has a broad market prospect. Similar products of this project are rarely used in animal husbandry and aquaculture abroad, and can be exported to foreign countries with developed aquaculture after they are officially put into production.

Development and research of marine biological pesticides with "double effects of medicine and fertilizer"

Project Description: This research topic mainly focuses on the preparation and application test of marine biological pesticides with double effects of medicine and fertilizer, and studies the separation and extraction of marine bioactive substances with biological pesticide function, and modifies the molecular structure of the extracted active components to improve their efficacy. Furthermore, marine biological pesticides with dual effects of medicine and fertilizer were prepared by compound synergistic means, and made into dosage forms suitable for practical application. Finally, the practical application effect of the prepared marine biological pesticides was investigated through indoor experiments and field experiments.

Study on the activity of marine biological compounds and their innovative drugs

Project Description: With the help of modern experimental technology, 66 monomer compounds such as terpenoids, steroids and alkaloids were identified, and new structural compounds with obvious anti-tumor activity were screened out, which laid the foundation for further research and utilization of these compounds. At the same time, the preclinical study of CPG, a new antiarrhythmic drug, solved the key technical problems in the evaluation of the efficacy and safety of CPG oligosaccharides. Haizhu oral liquid, as an ideal lipid-lowering and anti-arteriosclerosis drug, has been put on the market and has made some key technological breakthroughs and innovative intellectual property rights. This study will lay a foundation for further research and utilization, and has important economic, social and environmental benefits and scientific value, and provide scientific basis for government departments to scientifically manage, plan and develop the ocean.

Utilization technology of tropical marine bioactive substances

Project Overview: This achievement has developed the discovery and optimization technology of tropical marine bioactive compounds, the fixed-weight preparation technology of pearl aminoglycosides, the deodorization and detoxification technology of marine biological reverse osmosis column membrane combination and the fixed-length preparation technology of chitin aminooligosaccharides. Using this technology, about 900 kinds of tropical marine biological compounds were extracted and identified, of which about 1 19 was newly discovered in the world. Screening out 2 1 active compounds with anti-Alzheimer's disease, anti-tumor, cardiovascular and cerebrovascular diseases and 3 1 insect antifeedant and anti-attachment. Development of national drug standard new drugs 1 each, transformation of national drug standard brand drugs 1 each, development of 2 national health products, 2 provincial functional foods, development of 5 series of pearl cosmetics, and development of national key new products 1 each, namely amino oligosaccharide water-based biological pesticides.

Development technology of marine bioactive soybean milk

Project overview: The research contents of this technology include: pretreatment of fresh sea cucumber; Protein homogenization and denaturation treatment of sea cucumber: sterilization treatment; Study on degradation technology of compound biological enzyme-study on deodorization technology: study on concentration technology; Analysis of physical and chemical indexes and nutritional components of drinking water; Stability study; Study on extraction technology of soybean lecithin: study on microemulsion integration technology of soybean milk and nutrient solution. This study embodies the organic combination of marine biological products and land food, as well as the organic combination of animal and plant food. The new product will have a more comprehensive nutritional structure and contain no cholesterol, which will produce great social and economic benefits.

Marine biomaterials for skin tissue repair

Project Description: The new medical marine biomaterial developed by the Ocean "863" high-tech development project is mainly used for the repair of various skin damaged tissues, with the advantages of no irritation, safety, convenience, quick wound repair and no scar left. Has the international advanced level.

Complex enzyme and the development of marine collagen

Project Description: Enzyme-added chitosan health food combines high deacetylation degree chitosan with high-purity enzymes such as papain, bromelain, superoxide dismutase (SOD), amylase and lipase, and exerts the synergistic effect of complex enzymes and chitosan. Chitosan has a strong affinity with cells and can be used as a carrier to deliver components with therapeutic or health care functions to cells. Chitosan can protect the stability of enzyme, be degraded by enzyme and increase the proportion of oligosaccharides with anticancer activity. The product also contains some active ingredients of enzymes, as well as healthy ingredients such as selenoprotein, glucose and zinc. It can regulate gastrointestinal tract, improve digestion and absorption, and enhance physical fitness; Enhance immunity, improve resistance, diminish inflammation and sterilize; Scavenging free radicals, delaying aging, preventing cancer and beautifying.

Development of supporting technology for phycobiliprotein production process

Project Description: Physically extract phycobiliprotein natural food pigment from spirulina, and further improve the cell wall breaking technology, cell debris removal and its stability technology. Improve the extraction technology route of phycobiliprotein and the supporting technology of production process, and the contents of heavy metals and microorganisms meet the relevant food standards.

Production technology of marine biological health care product Gejianjing

Project Description: This product is suitable for adjuvant treatment of cancer patients, and has the functions of inhibiting cancer and reducing the toxic and side effects of radiotherapy, and does not damage normal cells of human body. Improve the quality of life; Has the functions of enhancing immunity and health care for normal human bodies; This product is taken from marine cultured shellfish-Meretrix meretrix, which is rich in resources. The product does not pollute the environment in the production process, so that the raw materials can do what they can, and lectin can be extracted from the extracted raw materials. The product is suitable for adjuvant treatment of cancer patients, and it is a nutritional health care product with nourishing, detoxicating and enhancing human immune function.

Composition analysis and extraction technology of biological polysaccharide from Meretrix meretrix

Project Overview: This project takes Meretrix meretrix, the second largest mariculture product in Guangxi coastal area, as raw material, and establishes the extraction process and purification method of Meretrix meretrix polysaccharide and lectin by using interdisciplinary research methods in the chemical field; Clam shell-enzymolysis-precipitation-purification-drying-Meretrix meretrix polysaccharide dry powder; Meretrix meretrix body fluid-precipitation-backwashing-drying-Meretrix meretrix agglutinin dry powder. This pap studied that regulation of animal immune function, inhibition of pathogenic bacteria and their dosage of Meretrix meretrix polysaccharide and lectin, and analyzed the contents of general components, nutritional component and functional components of Meretrix meretrix, as well as the composition and proportion of Meretrix meretrix polysaccharide and lectin, which provided detailed data for possible clinical trials in the future and laid a good foundation for the industrialization of Meretrix meretrix biological products. The research results have reached the advanced level of similar research in China.

Ocean hypoglycemic agent "2038"

Project Description: The development of science and technology has created unprecedented prosperity for mankind. High-speed industrialization has exhausted the natural resources of the earth, but it has also brought serious environmental pollution, ecological environment and changes in people's lifestyles. Some non-communicable diseases spread rapidly. In particular, senile diseases such as osteoporosis and diabetes have become the main enemies threatening the healthy life of middle-aged and elderly people. There are more than 30 million diabetics and 30 million people with impaired glucose tolerance in China. These people further develop diabetes, and the incidence of diabetes in large and medium-sized cities is 5%. The incidence of elderly people over 60 years old is much higher than this ratio. Marine hypoglycemic agent "2038" is a component extracted from marine organisms, which can lower blood sugar and then react with trivalent chromium ions to form new compounds. Its structure was confirmed by infrared spectrum, nuclear magnetic resonance, mass spectrometry and ultraviolet spectrum as a new chemical substance, and toxicological studies showed that it had no toxic and side effects. Taking mice as experimental objects, the dosage of 20,000 mg per kilogram of body weight was given orally 12 days, and there was no animal death and no adverse reaction, which was equivalent to 1200 times of the high-dose drug effect. "2038" has the function of protecting islets and can prevent some chemicals from damaging islets. Patent, Award-winning and Practical Application: "2038" has carried out pilot research, and hundreds of grams of samples can be obtained each time. The product quality is stable, the process is optimized, and the reaction can be carried out at normal temperature and pressure.

Chitin functional health food

Project outline: On the basis of a lot of work accumulation, the Institute developed a new generation of health food at the end of 1997. The main features of the second generation chitin functional health food are: 1. The raw material is crab shells from the ocean, and there is no chemical pollution. 2. By introducing functional genes into chitin molecules, the immune function of chitin can be further strengthened, and a strong immune effect can be achieved with a small dose. 3. Chitosan forms a cavity with moderate cavity by templating, and only heavy metals harmful to human body (such as lead and mercury) have strong adsorption, while metal ions harmless to human body (such as calcium and magnesium) have no adsorption, thus effectively eliminating heavy metals harmful to human body. 4. A large number of pharmacological experiments and the results of human self-feeding show that the best ratio of the two has the best dual effect.