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How long can you live with HIV if you have first-line drugs to control it, and what is the probability of developing drug resistance?

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The antiviral treatment of AIDS

In 1996, the world began to promote the use of antiviral drugs for the treatment of AIDS, the treatment method used is the cocktail therapy put forward by Prof. He Daiyi, whose main principle is To take a variety of antiviral therapy drugs, similar to cocktails, a variety of drug combinations, so as to inhibit the replication of the HIV virus appeared in the body, reduce the destruction of viral immune cells, so as to delay the disease after infection. This will slow down the disease process after the infection of AIDS and improve the quality of life of the AIDS patients.

So, what does the HIV antivirus go to include?

Since 2004, China has provided "four free and one care" policy for AIDS patients, providing free antiretroviral treatment for AIDS patients. Currently, the drugs used for antiviral treatment include first-line antiviral drugs and second-line antiviral drugs:

First-line drugs:

China's current treatment regimen for antiviral drugs is the first-line drugs for antiviral treatment, and its main strategies are:

Tenofovir (TDF)/Zidovudine (AZT)+Lamivudine (3TC)+Efavirenz ( EFV)/nevirapine (NVP)

The first-line drugs are tailored to different situations, allowing different combinations of these drugs to be used in the clinic as first-line drugs for antiviral therapy. Lamivudine is one of the drugs that must be treated for any condition, so these five antiviral drugs in different combinations make up the "cocktail" of HIV antiviral therapy. Naivel ;

Second-line drugs are generally an alternative treatment for HIV when first-line drug therapy is not too effective or when resistance to certain drugs has developed. The main thing is still the use of first-line drugs.

How long can I live on first-line drugs?

With regard to HIV antiretroviral therapy, whether you are taking first-line antiretroviral drugs or second-line antiretroviral drugs, as long as you follow the doctor's instructions for antiretroviral therapy on time and in accordance with the dosage, and to improve medication adherence, it is possible to effectively inhibit the replication of the virus in the body, and the international practice is that the common practice is that "undetectable = non-transmissible" (U=U). Therefore, to do the above rules of medication, then is the AIDS patient is possible to live as long as the life of a normal person!

The probability of HIV drug resistance

Long-term use of antiretroviral drugs, there is a possibility of drug resistance, that is, antiretroviral drugs to eat for a long time, not much effect, can not effectively inhibit the spread of the virus in the body, so this antiretroviral drug resistance, mainly related to the individual differences, some studies have pointed out that the probability of resistance to the drug may reach 28.1% (a study in Chongqing); but not every The antiviral treatment of the infected person will be resistant, therefore, if you take a combination of antiviral drugs for a long time after the drug, must be timely detection of their own CD4 level, because this is one of the biological indicators reflecting the effectiveness of treatment, If the CD4 cells in the taking of antiviral drugs, has been declining, indicating that the emergence of drug resistance , at this time should have in the

This is the first time that I've ever seen a person who has been on a drug for more than a year, and I've never seen one.

Whether taking first-line or second-line antiretroviral drugs for HIV treatment, the main thing is to take them on time and in accordance with the amount of time, not to be able to casually cut off the medication, and to improve compliance, so as to effectively inhibit the HIV virus and prolong the life of the patient! In addition, it should be noted that CD4 levels should be measured on a regular basis, at least once every six months for HIV patients taking medication, to determine whether the antiretroviral treatment is effective!

Personally, I feel that if you have guaranteed drug control, and then maintain a healthy and optimistic mindset and lifestyle, and often exercise, you should be able to fight drug resistance and live a long time

It is said that you can live to a normal life expectancy, but in fact, this is also depends on the individual's physical condition. But if you take your medication on time, you won't live a bad life, and you'll be a lot less likely to get sick. So if you get it, take your medication and be optimistic and maybe live to a ripe old age

For the treatment of AIDS drugs, in the international arena, a **** is divided into six categories, more than 30 kinds of antiretroviral drugs. Among them, there are nucleoglycolic acid reverse transcriptase inhibitors, such as lamivudine, tenofovir, zidovudine and so on. Stavudine is excluded as a first-line drug because of its toxic side effects.

Non-non-glycolic reverse transcriptase inhibitors are nevirapine, efavirenz, and others. Protease inhibitors include lopinavir, ritonavir, and others. Integrase chain transfer inhibitors are raltegravir, dolutegravir, and others. The preferred recommended regimen is emtricitabine, tenofovir, raltegravir, or dolutegravir.

AIDS, acquired immunodeficiency syndrome (AIDS), the pathogen is human immunodeficiency virus (HIV), also known as HIV. Currently, AIDS has become a serious threat to the public health of China's important public **** health problems. 21.7 million cases are receiving highly effective combination antiretroviral therapy "cocktail therapy", now also known as antiretroviral therapy.

How long do people live with HIV and what is the likelihood of developing drug resistance if they have first-line drug control?

China as a whole is a low-prevalence country for HIV, but because of its large population base, the absolute number of people living with HIV and AIDS patients is very large.

HIV-1 is the main prevalent strain in China, and 10 subtypes have been identified, as well as different prevalent recombinant types (CRFs), and the main prevalent subtypes of HIV-1 are AE recombinant and BC recombinant. a small number of people infected with HIV-2 have been found in some parts of the country since 1999.

The process of HIV infection in human cells includes:

(1) adsorption, membrane fusion, and penetration: after HIV-1 infects the body, it selectively adsorbs on the CD4 receptor of target cells and enters the host cell with the help of co-receptors;

(2) reverse transcription, nucleation, and integration: viral RNA in the cytoplasm forms complementary DNA under the action of reverse transcriptase. The viral DNA integrated into the host DNA is called "provirus";

(3) transcription and translation;

(4) assembly, maturation and budding.

The probability of developing resistance exists, but it can be controlled with the right therapy.

Chronic diseases such as hypertension, diabetes mellitus, dyslipidemia, coronary heart disease, cerebrovascular disease, non-HIV-related tumors (especially liver cancer, lung cancer, breast cancer, prostate cancer, colorectal cancer, etc.), chronic obstructive pulmonary disease (COPD), non-alcoholic fatty liver disease (NALFLD), and bone disease in infected patients need to be established according to HIV-negative patients, and screening and prevention should be carried out in accordance with the relevant guidelines. The company's website is a great source of information about the company's services.

I am Pharmacist Wang, insisting on spreading knowledge of diseases in simple and easy-to-understand words, and dedicating my own small contribution to a healthy China. If you found my answer helpful, please leave a like! In addition, if you still have related questions, welcome to leave a message, we *** with the discussion!

The main treatment for AIDS around the world is Highly Active Antiretroviral Therapy (HAART therapy), commonly known as cocktail therapy. If the diagnosis can be established at the early stage of viral infection of the human body, and under the guidance of the doctor as early as possible to take regular medication, regular checkups and follow-ups, the emergence of adverse reactions or drug resistance in a timely manner after the replacement of the drug, then the most ideal state is the infected person's life will not be affected by the disease, to live up to the life expectancy of a normal person. However, this ideal state is really difficult to achieve, which is not only related to the state of the infected person's own immune function, but also the number of invading viruses, the type of viruses, the body's response to the drugs, the speed of the development of viral resistance, and the emergence of resistance to drugs and whether they can be replaced in a timely manner. But overall the life expectancy of infected people who have received regular treatment is much higher than that of infected people who have not received any treatment.

Antiretroviral therapy is specific to the HIV pathogen. The average incubation period for HIV infection is 8-10 years, ranging from a few months to 15 years. Early detection of HIV infection and timely and standardized treatment can maximize the suppression of viral replication, rebuild or maintain immune function, reduce the rate of death and related diseases, improve the quality of life, and increase life expectancy. HIV treatment is commonly known as "cocktail" therapy, which aims to prevent the development of drug resistance and improve drug efficacy. With the continuous research and development of antiviral drugs, I believe the efficacy will be better and better, as long as the standardized treatment will avoid the occurrence of drug resistance.

Do a good job of compliance, on time medication, first-line drug resistance, there is a second line of drugs, the second line of drugs do not have self-financed drugs! Relax, is the main thing. The first thing you need to do is to take it easy, that's the main thing!

Look at the economic condition of the patient, take Magic Johnson, from the discovery of HIV infection has been the past three decades, he has a team, dedicated to using the most advanced and appropriate treatment methods to maintain his life and health. Most people who don't have the same condition as he does may be able to afford it for a couple of years. ......