What are the main disadvantages of hormone replacement therapy?

The main disadvantage of hormone replacement therapy is that long-term stimulation with estrogen alone can lead to endometrial hyperplasia and even cancer. Early hormone replacement therapy used a single estrogen, and the results showed that the incidence of endometrial cancer was significantly higher than in the normal population. The effect on the incidence of breast cancer has not been clearly concluded.

In summary, hormone replacement therapy has more advantages than disadvantages for the health of menopausal women, and the disadvantages can be minimized through rational use of medication.