What is the mechanism of nucleotide drugs in treating hepatitis B? What is the mechanism of interferon in treating hepatitis B? Does the former kill the virus and the latter transform the virus?

The antiviral mechanism of 1 nucleoside (acid) analogues: it acts on the polymerase region of HBV, and stops the extension of polymerase chain by replacing the nucleoside with similar structure needed to extend the polymerase chain during virus replication, thus inhibiting virus replication. Therefore, this treatment only inhibits the replication of the virus to the greatest extent, and will not kill the hepatitis B virus. It will rebound after stopping taking the medicine.

2. Mechanism of interferon in the treatment of hepatitis B: After interferon binds to interferon receptor located on the surface of liver cells, it transmits the signal of interferon to the nucleus, and activates the gene activated by interferon, thus expressing a series of protein to realize the function of interferon, and then activating the production of protein with other special functions, so as to achieve the effect of antivirus or immune enhancement. In fact, it mainly works through immune regulation. The biggest function of interferon is to completely eliminate hepatitis B virus after a limited course of treatment with the help of the activation of patients' own immunity, so as to achieve a lasting response after stopping taking drugs.