Excuse me, Hefei Yun Ge Fluid Technology Co., Ltd., which is better, the traditional process to purify resveratrol or the membrane concentration process?

Resveratrol is odorless, insoluble in water, soluble in organic solvents such as ethanol and acetone. It is a natural antioxidant, which can reduce blood viscosity, inhibit platelet aggregation and vasodilation, keep blood smooth, prevent the occurrence and development of cancer, and prevent and treat atherosclerosis, coronary heart disease, ischemic heart disease and hyperlipidemia.

Our company once worked on a resveratrol project in a pharmaceutical company in Chongqing. The traditional plate-frame filtration process and mesh membrane separation process were comprehensively compared.

Traditional process of resveratrol: In the traditional extraction and production process of resveratrol, the ethanol solution is filtered by a plate frame, the filtrate is put on an alumina column, the lower column liquid is decolorized by activated carbon, and then the finished product is obtained by crystallization. The flow chart is as follows:

Dissolution of crude ethanol → plate and frame filtration → decolorization of activated carbon → alumina column → crystallization → product.

Defects in the traditional process of resveratrol;

During the dissolution of 1. ethanol, the dissolution was incomplete, and some undissolved effective components were intercepted in the process of plate and frame filtration, and the loss rate of effective components was 5%.

2. The plate-and-frame filtration process is complex, and the manual labor intensity is high, and the filter paper and filter membrane are replaced commonly.

3. Because the plate and frame filtration accuracy is not high, resveratrol solution can not be decolored and impurity removed, so when loading alumina column, the loading speed is slow and the consumption of alumina is large; In the process of alumina activation and reuse, the loss is about 5% each time.

4. The color of resveratrol solution is dark, and the color of the lower column solution still meets the requirements of crystallization, so it must be decolorized by activated carbon, and the dosage is about 0.7%; In the process of activated carbon adsorption, the adsorption loss of effective components is about 0.36%.

5. Resveratrol has not been purified by high-precision filtration in the whole process, so the purity of the crystallized product is low.

To sum up, the production process of resveratrol is aging, complex and labor-intensive. A lot of filter paper, filter membrane, alumina and activated carbon are consumed in the process, and the content loss is great, so the purity of the obtained product is not high. It greatly increases the production cost of enterprises and reduces the market competitiveness.

Hefei Yun Ge Fluid Technology Co., Ltd. analyzed the current process status of production enterprises, and adopted advanced membrane separation technology combined with traditional technology to carry out technological innovation and process optimization. After many experiments and technical analysis, the application of membrane technology combined with alumina column in the preparation of resveratrol was successfully developed. The production process was optimized, which saved the investment of filter paper, filter membrane and alumina, replaced the adsorption of activated carbon, and improved the purity and yield of products. It reduces the cost of production enterprises, brings better products and increases the market competitiveness.

Schematic diagram of resveratrol membrane filtration process:

Dissolution of crude ethanol → membrane clarification and filtration → membrane decoloration and impurity removal → alumina column (a small amount of alumina) → crystallization-product.

Advantages of resveratrol membrane filtration technology;

In the process of dissolving 1. ethanol, the effective components that are not completely dissolved are further dissolved in the process of membrane clarification and circular filtration, which reduces the loss of effective components.

2. The membrane clarification and filtration precision is high, and part of macromolecular pigments and impurities can be removed, which is convenient for membrane decolorization in the later stage.

3. Membrane clarification and filtration are carried out in cross-flow mode, which is not easy to be blocked, automatically cleaned online and has long service life.

4. The membrane decoloration and impurity removal process is simple, automatic control and convenient operation.

5. The effect of membrane decoloration and impurity removal is stable, and the speed of filtrate passing through alumina column can be doubled compared with the traditional process, which greatly saves the consumption and input cost of alumina.

6. The color of filtrate after membrane decoloration and impurity removal can directly meet the crystallization requirements after passing through alumina column, which can completely replace the traditional activated carbon decoloration and save the investment cost of activated carbon.

7. The filtrate after membrane decolorization and impurity removal passes through alumina column, and the purity of crystallized product can reach over 99%.

To sum up, the membrane separation technology combined with the new technology of alumina column and automatic control design system greatly reduces the labor intensity, simplifies the production process, saves the consumption of alumina and activated carbon, saves the cost, improves the production efficiency and improves the product quality.