How to develop anticancer drugs by using the knowledge of drug molecular biology

In the past, pharmacy only paid attention to the knowledge of traditional chemistry, synthesis, pharmacy and drug analysis, but neglected the systematic study of biochemistry, cell biology and molecular biology, which was related to the knowledge of the older generation of pharmacy professionals and the research and development ideas of generic drugs in China. But the reality is that no matter what drugs are developed today, they must involve macromolecules and biological system structures, not just the development of anticancer drugs.

DNA determines the expression of protein, protein's conception determines the combination with drug molecules, and determines the way and intensity of drugs affecting body functions, especially tumor-targeting drugs. Gene mutation leads to different therapeutic effects of targeted drugs. Therefore, in the design stage and in vitro screening stage of drug molecules, we must make good use of the knowledge of molecular biology to fully study the molecular pharmacological characteristics and relationship between biological macromolecules and small drug molecules or antigens and antibodies, so as to lay a good foundation for further preclinical and clinical research.