How do B lymphocytes mature?

Early embryo is produced, differentiated and matured in the island of hematopoietic cells of embryonic liver (fetal liver), which is gradually replaced by bone marrow, and later it is produced, differentiated and matured in bone marrow after birth. B lymphocytes B lymphocytes B lymphocytes are mainly derived from hematopoietic stem cells in bone marrow. Early embryo is produced, differentiated and matured in the island of hematopoietic cells of embryonic liver (fetal liver), which is gradually replaced by bone marrow, and later it is produced, differentiated and matured in bone marrow after birth. Mature B cells mainly reside in peripheral lymphoid tissues, such as lymph nodes in the superficial cortex of lymph nodes, lymph nodes in the red pulp of spleen and white pulp. B cells can differentiate into plasma cells under the stimulation of antigen, synthesize and secrete immunoglobulin, and mainly carry out humoral immunity of the body. Compared with T lymphocytes, it is slightly larger. These lymphocytes will proliferate and differentiate into a large number of plasma cells after being stimulated by antigens. Plasma cells can synthesize and secrete antibodies and circulate in the blood.