What is the function and efficacy of ginsenoside?

Ginsenosides mainly exist in the medicinal materials of ginseng and potato, and are regarded as the active components of ginseng, belonging to sterols, also known as triterpenoid saponins. Its main functions include improving immunity, resisting bacteria, improving blood supply deficiency of cardiovascular and cerebrovascular diseases, regulating central nervous system, resisting fatigue and delaying aging.

Ginsenosides are characterized by similar structures, all of which contain 30 carbon atoms and are arranged in four rings. According to the different structures, it can be divided into dammarane type and oleanane type, and its curative effect and function are also different. There are many kinds of ginsenoside, such as ginsenoside Rb 1. Rb2.Rb3.Rh.Re, etc. , their effects are slightly different, as shown below:

1. Main efficacy and function of ginseng soap Rh2. Is to inhibit the metastasis of cancer cells to other organs, enhance the body's immunity, and quickly restore physical fitness;

2. ginsenoside Rg 1. It has the functions of exciting central nervous system, resisting fatigue, improving memory and learning ability.

3. Ginsenoside Rg2. It has anti-shock effect, can quickly improve myocardial ischemia and hypoxia, and treat and prevent coronary heart disease;

4. Ginsenoside Rg3 has a certain anti-tumor effect, which can inhibit cancer cell infiltration, anti-tumor cell metastasis and promote tumor cell apoptosis.

In a word, ginsenoside is a very important pharmaceutical ingredient, and it is also widely used in clinic.

1. Ginsenoside is a sterol compound, triterpenoid saponin. It mainly exists in ginseng. Ginsenoside is regarded as the active ingredient in ginseng, so it has become the research object. Because ginsenoside affects many metabolic pathways and its efficacy is complicated, it is difficult to separate the monomer components of various ginsenoside. From the United States to all over the world, the general public's enthusiasm for herbal medicine and the growth of alternative medical care have led to a large number of studies on ginsenoside. In the United States, the annual sales of ginseng exceeds 300 million dollars, accounting for 15% to 20% of the herbal medicine market, so ginseng is one of the most commonly used Chinese herbal medicines for American consumers.

In the United States, ginseng preparations are listed as dietary supplements; But in Europe, especially in Germany, ginseng is regarded as a medicine. In several European countries, ginseng and other herbs are used as prescriptions by doctors, and the principles of plant medicine are once again taught in medical schools. In the special issue of E Committee on setting the safety and effectiveness of herbal medicines, the German government recognized ginseng as a tonic to eliminate fatigue and fatigue.

2. Dammam types include two types: panaxadiol type -A, and glycoside is 20(S)- protopanaxadiol. It contains the most ginsenoside, such as ginsenoside Rb1.rb2.rb3.rc.rd.rg3.rh2 and glycosyl PD; Panaxatriol type -B type, glycoside is 20. (S)- protopanaxatriol. It contains ginsenoside Re, Rg 1, Rg2, Rh 1 and glycosyl PT. Oleanane type: oleanolic acid type -C type, and the glycoside is oleanolic acid. Total saponins do not hemolyze, type A anti-hemolysis, type B and type C hemolysis.

Thirdly, 5 μg/ml ginsenoside Rh3 can obviously inhibit the proliferation of SW480 cells for 48 h, and its effect is enhanced with the increase of dose and the extension of action time. 30 μg/ml ginsenoside Rh3 acted for 72 h, and the inhibition rate was over 80%. 1.5μ g/ml ginsenoside Rh3 induced partial apoptosis for 24 h, and the cytoplasm was brown, and the number of apoptotic cells increased after 72 h; The apoptosis rate of 15 μg/ml ginsenoside Rh3 for 24 h was 25.5%, and that of 20 μg/ml ginsenoside Rh3 for 24 h was 3 1%, and no cell necrosis was found. 15 μg/ml ginsenoside Rh3 treated for 72 h, the apoptosis rate was 55%, and the necrosis rate was 7%. Conclusion Ginsenoside Rh3 can inhibit the proliferation of human colon cancer cell SW480 and induce its apoptosis in a dose-and time-dependent manner.