Application of biochemical separation method in separation and purification of penicillin

Pretreatment technology: heating, pH adjustment, flocculation cell separation technology: sedimentation, centrifugal separation, filtration, cross-flow filtration, cell fragmentation technology: homogenization, grinding, cell debris separation technology: centrifugal separation, extractive filtration, cross-flow filtration, primary purification technology: precipitation, adsorption, extraction and ultrafiltration, and high purification technology: chromatography, ion exchange, affinity and hydrophobicity.