Among the following historical figures, A, Zhang Heng, B, Jia Sixie, C, Cai Lun and D, Zu Chongzhi contributed the most to the spread of human culture.

Test and analysis: analyze the topics and put forward the problems that have contributed the most to the spread of human culture. Item A is the astronomer who invented the seismograph, item B is the agronomist, item D is the mathematician, and item C is the Cai Lun who improved papermaking, making paper cheaper and more widely used, and contributing to the spread of culture.

Comments: This question is moderately difficult. To examine students' ability to analyze and distinguish historical figures and answer this question, we must first have the ability to remember four historical figures, and then have the ability to analyze and distinguish four historical figures. For historical figures, we should not only be familiar with their actions, but also understand their positive influence on society, so as to answer questions smoothly.