What is the difference between China's recombinant COVID-19 vaccine and American mRNA vaccine?

The recombinant COVID-19 vaccine developed by China belongs to recombination vaccines. This is a genetic engineering recombination vaccines technology widely used in the world, which can speed up the time compared with the traditional inactivated vaccine technology.

The American mRNA- 1273 vaccine belongs to the mRNA vaccine. This is an anti-novel coronavirus messenger RNA (mRNA) vaccine, which can target the spike protein of the virus.

Second, the principle of action is different

The recombinant COVID-19 epidemic developed in China is to clone the gene fragment of the virus and then put it into bacteria for replication and expression. When there is enough, it is extracted as antigen to prepare vaccine.

The basic principle of American mRNA- 1273 vaccine is to inject the mRNA carrying the instruction of cell to make antigen protein into human body, and then it is swallowed by human cells. The protein factory in the cell will produce antigen protein that can stimulate the immune system, such as novel coronavirus's S protein, which can stimulate the body to produce antibodies against the virus.

Third, time and risk are different.

Compared with the recombinant COVID-19 vaccine developed in China, the American mRNA- 1273 vaccine can bypass the animal experiment stage and directly enter human trials, which will also save time and cost. Although it is extremely advanced, the risk factor is relatively high.

Public trust. An American COVID-19 vaccine entered clinical trials.

What does it mean for Phoenix Net-Chinese and American vaccines to enter the clinical trial stage at the same time?