What is the production process of tablets?

Process:

Raw material processing: if the needle, tablet crystallization needs to be crushed, to overcome the poor compressibility

Making soft material ※ Add the amount of binder

Granulation: choose the sieve mesh aperture, according to the tablets, tablets, the weight of a large or small choice.

Drying: 50~60°C, controlled according to drug stability.

Results: water content in granules 1~3%,

More: sticky punch; less: lobes, loose tablets

Full granulation: add disintegrating agent, lubricant mixing well.

Boiling bed one-step granulation method.

Tablets: refers to the use of compression or molding method made of drug-containing tablets (or other shapes) solid preparations. Can be divided into two categories:

Pressing tablets: rely on external pressure to the drug or drug-containing mixture (powder, granules, crystals, etc.) compressed into. Such as: ordinary round tablets, shaped tablets, pressed coated tablets.

Molded tablets: the use of suitable tools pouring drug-containing liquid: drying, cooling and curing method and molding. Such as: paper type tablets, oral instant tablets (freeze-drying technology, PEG solid dispersion technology)

1. Granulation and pressing tablets: wet and dry method

Purpose: to increase the fluidity, compressibility, to prevent delamination and dust.

Wet granulation is the conventional granulation process, but for wet, heat unstable drugs should be dry granulation.

2. Direct compression: powder, crystallization, prefabricated granules

Advantages: simple process, good reproducibility, quality control

Requirements, raw materials and auxiliaries crystal type is good, square crystals, columnar crystals, spherical crystals

Flake crystals, needle crystals are not good.