Does tadalafil have big side effects?

1In March, 1998, the FDA of the United States officially approved the marketing of sildenafil, which is a type 5 phosphodiesterase (PDE5) inhibitor, and achieves the purpose of erection by dilating the blood vessels supplying the cavernous body. This drug is not an "aphrodisiac" in the traditional sense, and it will not cause sexual excitement in itself. It can only take effect after sexual stimulation.

Because of the obvious curative effect and small side effects, the related research has also advanced by leaps and bounds. In 2003, two similar drugs were listed one after another, namely vardenafil and tadalafil. However, in 2007, a survey was conducted among 70 men aged 28-85, and it was found that 100% of men knew sildenafil, 1 knew vardenafil, no one knew tadalafil, and only 5 of 70 men had taken sildenafil. The awareness rate of medication time, contraindications and side effects. Less than 10%. Therefore, it is necessary to popularize the science of three drugs.

Sildenafil is the most common drug. After taking sildenafil 100mg, more than two-thirds of the subjects began to erect within 30min under effective stimulation, and obtained sufficient hardness. The peak time of sildenafil concentration is 65438 0 hours, and the half-life is about 3-5 hours. High-fat diet can slow down the absorption of sildenafil, and the peak time of drug concentration will be prolonged by 30 minutes, reaching 1 hour, so the drug should be taken about 30-60 minutes before sexual life, preferably 2 hours after meals.

The recommended dose of vardenafil is 10mg, which is characterized by rapid onset, the drug concentration will reach the peak concentration in about 60 minutes, and it is also easily affected by meals.

The pharmacokinetics of tadalafil is also variable, showing that the peak time of tadalafil concentration is about 0.5 ~ 12h, the half-life is 17.5h, and the action can last for 24 ~ 36h. It can be seen that the drug takes effect faster and lasts longer.

For comparison, you can refer to the following table:

Note: The three drugs interact with other drugs, especially it is forbidden to take them with nitrate drugs.

Nitrates: such as isosorbide mononitrate and nitroglycerin.

Some antihypertensive drugs: such as calcium channel blockers.

Alpha blocker: It can treat hypertension or prostatic hypertrophy.

Protease inhibitors: a class of anti-AIDS drugs

Antifungal drugs: such as ketoconazole and itraconazole.

Antibacterial drugs: such as clarithromycin

Avoid excessive drinking when using these three drugs, and the three drugs cannot be used together.

Tadalafil is the protagonist of today, and today I will focus on:

Read the instructions first.

In other words, the drug, like sildenafil and vardenafil, can be taken as needed, at least 30 minutes before sex, and continuous taking is not recommended.

20 18 China andrology magazine published "tadalafil 5mg once a day for erectile dysfunction", which is the knowledge of domestic experts. I extracted a part:

Based on the risk factors, etiology and pathogenesis, long-term and regular treatment and management (follow-up) is not only beneficial to the treatment of ED, but also helps to prevent the occurrence and development of its potential primary disease, which is beneficial to the overall health and conforms to the principle of chronic disease management. Long-term regular therapy is a new treatment method for ed patients based on in-depth understanding of the pathogenesis of ED in recent years. Because of its long half-life of 17.5 hours, tadalafil is the only PDE5 inhibitor approved by the US Food and Drug Administration (FDA) and China China Food and Drug Administration (CFDA) for once-a-day treatment of ed ... Long-term regular treatment, once a day, can not only dilute the relationship between medication and sexual life, improve patients' psychological benefits, but also improve vascular endothelial function (the co-pathogenesis of ED and its potential chronic diseases).

According to domestic and foreign literature reports and domestic clinical experience, tadalafil 5mg once a day is suitable for almost all ED patients without drug contraindications, especially recommended for the following patients.

(1) Patients with high frequency of sexual intercourse, patients with spontaneous sexual life, patients with newly-married or ovulatory ed, and patients susceptible to psychological factors or drug suggestion.

(2) Patients with poor effect or great side effects after taking as needed.

(3) ED patients with lower urinary tract symptoms.

(4) Patients with ED after radical prostatectomy with nerve preservation.

(5) Combined androgen therapy for ed patients with hypogonadism.

(6) ED patients with chronic diseases (diabetes, cardiovascular diseases, etc.). )

How to use tadalafil 5 mg once a day

(1) dose

The recommended daily therapeutic dose is 5mg, which can be adjusted according to the severity and therapeutic effect of ed patients. Severe ED can be taken from 10mg daily, and then gradually reduced according to the therapeutic effect.

(2) Course of treatment

The course of ED is not strictly required, generally more than 3 months, which needs to be decided according to the improvement of erectile function. Such patients should maintain a moderate frequency of sexual life, such as 1~2 times a week, and should also be evaluated regularly, generally with 1 month as the shortest evaluation cycle.

Therefore, tadalafil can be taken as needed or in small doses for a long time.

Reminder: This medicine is a prescription drug. Be sure to consult a doctor before taking it, especially for patients taking other drugs. Pay attention to drug interaction, especially don't use it with α -blockers and nitrates.