What is the function of Eupatorium odoratum?

1, enhancing immunity

Enhance the phagocytosis of leukocytes and increase the serum properdin. In the treatment of chronic bronchitis, the synthetic Houttuynia cordata Thunb can significantly improve the phagocytosis of white blood cells to Staphylococcus albus and serum properdin. Rabbits are injected with 8 mg of houttuynia cordata every day. After 3 days of continuous administration, the serum properdin also increased significantly. Houttuynia cordata Thunb can improve the body's immunity, which is of great significance for the treatment of sexually transmitted diseases.

2, antibacterial effect

Yellow oily substance extracted from Houttuynia cordata Thunb. It has inhibitory effect on a variety of microorganisms (especially yeasts and molds), and has obvious inhibitory effect on hemolytic streptococcus, staphylococcus aureus, influenza Bacillus, streptococcus and pneumococcus. It also has effects on Escherichia coli, Shigella dysenteriae and Salmonella typhi. The synthetic adduct of sodium bisulfite of decanoyl acetaldehyde is called synthetic houttuynia cordata Thunb. Sodium bisulfite adduct of dodecylaldehyde is called rhodopsin, which has obvious inhibitory effect on many bacteria in vivo and in vitro: the MIC of drug resistance to Staphylococcus aureus and penicillin is 62.5 ~ 80 mcg/ml, and that of influenza Bacillus is 1.25mg/ml. The strain H37RY of Mycobacterium tuberculosis was 65438 0 6 mcg/ml in Bai Pu liquid medium. On the improved Sutong semi-solid medium, it is 25mcg/ml, and its potassium salt is 12.5mcg/ml. The synthetic isoniazid houttuynia cordata Thunb has a strong effect on mycobacterium tuberculosis, and its MIC is 0.78 ~ 3. 1 mcg/ml, which is harmful to mice infected with tuberculosis. It can obviously prolong the survival time, and intraperitoneal injection of 1mg can prolong the survival time of mice by 62 days, and the mixed feeding effect is better.

3. Virus action

The primary monolayer epithelial cells of human fetal kidney were cultured. Houttuynia cordata decoction (1: 10) inhibited influenza A (Asia A) strain 68- 1 and delayed the growth of orphan virus Echo1. Zhu Yutong reported that several non-volatile oil fractions were obtained by ethanol extraction. Among them, houttuynia cordata. ⅲ has preventive and protective effects on mice infected with influenza virus, but has no obvious effects on EMC and HSVⅱⅱ. Synthetic derivatives of houttuynia cordata Thunb. It also has a strong antiviral effect. Houttuynia cordata Thunb The extract (4g crude drug /ml) has obvious preventive and protective effects on mice infected with influenza virus. However, it has no obvious protective effect on cerebral myocarditis virus and herpes virus type II infection. It is proved that the anti-influenza virus component of Houttuynia cordata Thunb is not in volatile oil, but in non-volatile oil. In vitro experiments show that the water extract of Houttuynia cordata Thunb can inhibit the infection of herpes simplex virus 1 type and type 2, and its specific mechanism is to inhibit the transcription factor activity required for virus replication. ?

4, diuretic effect

Perfusion of toad kidney or frog web with houttuynia cordata extract can dilate capillaries, increase blood flow and urine secretion, thus playing a diuretic role. Its effect may be caused by organic matter, and potassium only plays an additional role in increasing diuresis. When it acts directly, it can weaken the activity of leptospira-death-dissolution, and also delay the onset of guinea pigs artificially infected with leptospira.

5. Compatibility with TMP

Compared with TMP, Yongheng Zhang reported 0.75mg/ml Houttuynia cordata group and 0.75mg/ml Houttuynia cordata -7.5mg/mlTMP compatibility group (t = 5.6) p < 0.00 1, with a very significant difference. The compatibility group of 0.75mg/ml Houttuynia cordata -7.5mg/mlTMP was significantly different from that of 7.5mg/mlTMP (t = 2.78) P < 0.0 1. The results show that the antibacterial effect of the combination of them is better than that of the single use, and they have synergistic effect. 0. 1ml/ml houttuynia cordata volatile oil has no bacteriostatic effect, and the compatibility group of 0.1ml houttuynia cordata volatile oil -7.5mg/mlTMP is compared with the compatibility group of 7.5mg/mlTMP (t = 4.2) P.

6, the role of pathogenic microorganisms

Houttuynia cordata fresh juice has inhibitory effect on Staphylococcus aureus, and the effect is weakened after heating. Houttuynia cordata decoction can inhibit a variety of Gram-positive bacteria and Gram-negative bacteria, such as Staphylococcus aureus, Staphylococcus albus, hemolytic streptococcus, pneumococcus, cocci carinii, diphtheria bacillus, Proteus, Shigella flexneri, Shigella sonnei, Enterobacteriaceae, etc. The ether extract of Houttuynia cordata Thunb has obvious inhibitory effect on Mycobacterium tuberculosis in vitro. An oil extracted from Houttuynia cordata Thunb can effectively resist various microorganisms (especially mold and yeast). It also has inhibitory effect on Escherichia coli, Shigella and typhoid, but it is also reported that the antibacterial effect of Houttuynia cordata decoction is not obvious.

7, the role of the immune system

Houttuynia cordata decoction can obviously promote the phagocytosis of human peripheral blood leukocytes on Staphylococcus aureus in vitro. Synthetic Houttuynia cordata can improve the phagocytosis of leukocytes in patients with chronic tracheitis and improve the serum properdin level of rabbits and patients. ?

8. Antitumor effect

The inhibitory effect of new houttuynia cordata on Ehrlich ascites carcinoma may be related to the increase of cAMP level in cancer cells. The results showed that the total number of cancer cells, the division index of cancer cells and the amount of ascites were significantly reduced by intraperitoneal injection of different doses of new houttuynia cordata at different times, but the level of cAMP in cancer cells increased.

9. Anti-inflammatory effect

Houttuynia cordata decoction has significant anti-inflammatory effect on formaldehyde-induced foot swelling in rats, and can also significantly inhibit the thermal denaturation of human gamma globulin in the presence of Cu++. Houttuynia cordata Thunb can significantly inhibit the ear swelling and skin capillary permeability of mice caused by croton oil and xylene, and also significantly inhibit the dye exudation of abdominal capillary caused by HCA. Flavonoids such as quercetin, quercitrin and isoquercitrin contained in Houttuynia cordata Thunb. also have significant anti-inflammatory effects, which can significantly inhibit telangiectasia in the early stage of inflammation.

Extended data

Houttuynia cordata Thunb HOUTTUYNIAE (English name: Houttuyniae) is a herb included in China Pharmacopoeia, which comes from the dry aerial parts of Saururaceae (Latin name: Houttuynia cordata Thunb). ). In summer, stems and leaves are lush, flowers have been cut for a long time, and impurities are removed and dried.

Materia Medica: The stem is oblate and twisted, with a length of 20-35cm and a diameter of 0.2-20-35cm; The surface is brown, with several longitudinal edges and obvious nodes, and there are residual fibrous roots on the lower nodes; Fragile and easily broken. Leaves alternate, the leaves are folded and shrunk, and after flattening, they are heart-shaped, 3 ~ 5 cm long and 3 ~ 4.5 cm wide; Apex acuminate, entire; The upper surface is dark yellow-green to dark brown, and the lower surface is grayish green or grayish brown; The petiole is slender, and the base is combined with stipules to form a sheath. Spike terminal, yellow-brown. Crushed smells like fish. Baidu Encyclopedia-Houttuynia cordata