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What is the reason why traditional liquid-liquid chromatography is not recommended?

The reason why traditional liquid-liquid chromatography is not recommended is that the filtration sieve plate of the column head is blocked or polluted. . The filler in the column head of traditional liquid-liquid chromatography is polluted by the sample, and the salt in the buffer in traditional liquid-liquid chromatography column meets high concentration of methanol or other things. So the traditional liquid-liquid chromatography is not recommended.