Traditional Culture Encyclopedia - Traditional customs - In the research and development of modern new drugs, traditional pills are often not the main choice of dosage forms. What is the reason for this phenomenon?
In the research and development of modern new drugs, traditional pills are often not the main choice of dosage forms. What is the reason for this phenomenon?
1, quick and efficient. The dissolution time of dripping pills prepared with water-soluble matrix is mostly 5 ~ 15 minutes, not more than 30 minutes. After sublingual administration, it can be directly absorbed into the blood through oral mucosa, and it takes effect quickly. The dissolution of dropping pills increases with the increase of surface area, which can improve the dissolution performance of drugs and accelerate the dissolution rate, thus improving the bioavailability of drugs and making drugs play an efficient role. Compound Danshen dripping pills can be dissolved in 5 minutes.
2. Slow release and long effect. The solid dispersion dripping pills made of fat-soluble carrier can be slowly released from the carrier, maintain the required drug concentration, and have sustained release and long-term effects.
3. Reduce toxicity and side effects. Traditional Chinese medicine is generally large in size, large in dosage and poor in taste, and some drugs have stimulating effects on gastrointestinal tract. Dropping pills made by solid dispersion technology can increase the solubility and absorption rate of effective components, thus reducing the dosage and irritation to gastrointestinal tract.
4. Stable performance and low loss rate.
5, the dosage is small, which is convenient for storage, transportation, carrying and use.
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