Excuse me, about the pharmacokinetics of berberine.

Berberine has two effects on liver drug enzymes. It has different effects on different liver drug enzymes, including induction, cyclic nucleotide phosphodiesterase, isocitrate dehydrogenase 3, myocardial yellow enzyme and glucose -6- phosphatase, and inhibition includes uridine diphosphate-glucuronosyltransferase, cytochrome P4502E 1, glutathione S- transferase 1 and 65438.

It has little effect on the kidneys.