What are the main points of preparing granules?

In order to measure the accurate content of vitamin C, the experimental process should pay attention to: 1, the measurement of the liquid must be accurate, pay attention to the reading line of sight must be with the liquid concave surface of the lowest level.　　2, titration must control the titration speed, do not drop too much 2,6 a dichlorophenol indophenol solution at once, resulting in over-titration. If such a situation occurs to do it again, can not be tricky.　　3, the titration process should pay attention to observe the color of the solution in the conical flask, accurately determine the end point of the titration, that is, with a slight red color can be maintained for 15 seconds without fading until the end point of the titration, and each time the end point of the slight red color should be taken to the same standard, that is, the degree of reddening to be the same.

The key is the granulation technology, different varieties of starch, plant fiber, adhesion, excipient needs are not the same granulation technology needs to be adjusted according to different varieties

The preparation process of Chinese medicine particles general rule is: selection of materials → decontamination → industrial extraction → concentration → drying → granulation.

In order to improve the quality of finished granules and ensure the efficacy of clinical use, pharmacists have conducted extensive experimental

research. For example, in the granulation process, the workers have been able to

improve the quality of the granules and improve their properties by selecting better excipients and improving the process conditions. In the excipients, in addition to sugar powder, dextrin, soluble starch, but also

selected maltodextrin, lactose, microcrystalline cellulose, micronized silica, hydroxypropyl starch, etc.; in the process of changing the

traditional process of drying a long time, the loss of more thermally unstable components of the herbs of the shortcomings of the use of dynamic extraction, true

space low-temperature drying or instantaneous spray drying, dry granulation, High-speed mixing granulation and other new technologies.