Several new dosage forms of traditional Chinese medicine with market prospect

Cataplasm Chinese traditional medicine cataplasm refers to an external preparation made by uniformly mixing drug extracts, drugs and a suitable hydrophilic matrix and coating them on cloth. Microencapsulation Microencapsulation is a new formulation that uses natural or synthetic polymer materials or polymer film materials to wrap drugs. The volatile oil contained in aromatic Chinese medicine has a low boiling point, is volatile and insoluble in water. After being made into microcapsules, it can not only prevent its volatilization, but also be convenient to carry and take. The advantages of microcapsules are: they can prolong or control the release of drugs and make long-acting preparations; Capsules have the functions of isolating the outside world from drugs, preventing oxidation, hydrolysis and volatilization of drugs, and covering up bad smells; Can reduce the incompatibility of prescription preparations. For example, Vitex negundo oil for the treatment of chronic tracheitis has been improved several times, from decoction, gelatin pills to dripping pills. Now, after being made into Vitex negundo microcapsule tablets, it not only has the advantages of solving the bad smell and strong drug stability by gelatin pills and dropping pills, but also can reduce the adverse reactions of digestive tract and prolong the drug action time. Magnetic microcapsules and PH-sensitive microcapsules with special properties can also play the role of targeted drug release, which is a brand-new dosage form of Chinese patent medicine. The research of liposome preparation as drug carrier preparation has always been paid attention by pharmaceutical workers. In recent years, with the continuous development of biotechnology, the preparation technology of liposomes has been gradually improved. Liposomes have the advantages of non-toxicity, non-immunogenicity, being suitable for in vivo degradation, protecting encapsulated drugs, relieving and controlling drug release, targeting, improving drug efficacy and reducing toxic and side effects. Therefore, it is more and more important and widely used to wrap drugs with liposomes. There are many reports on the in vivo study of anticancer drugs using liposomes as carriers. Such as etoposide liposome, ginsenoside and human erythrocyte membrane lipid harringtonine liposome. Sustained-release controlled-release preparation Sustained-release preparation can reduce the times of taking medicine, provide relatively stable blood concentration, and achieve the purpose of reducing side effects and maintaining lasting drug effect. For example, the ethyl acetate extract contained in tripterygium wilfordii sustained-release tablets is equivalent to that of ordinary tablets, and the daily dosage is the same, but the bioavailability is high and the side effects are light. The controlled-release preparation automatically releases the drug from the dosage form to the active organ or the specific target site at a certain speed within a predetermined time, so that the blood drug concentration is kept within the effective concentration range for a long time, and the drug release is uniform and stable. The release rate of the controlled release system has nothing to do with time, which avoids the "peak-valley" phenomenon of the administration frequency of traditional conventional preparations and improves the safety and effectiveness of clinical medication.