What is the process of making tablets?

Wet granulation and tabletting process of tablets

Raw and auxiliary materials-crushing, sieving-mixing, making soft materials-granulating-drying-grading-total mixing-tabletting-coating.

Usually, dried particles need to be treated. When particles adhere to each other and agglomerate in the drying process of box dryer, it is necessary to screen them with a swing granulator with a suitable screen. Usually, the particles dried in fluidized bed have no adhesion.

According to requirements, disintegrants, lubricants, glidants, etc. are added. Put into dry granules and mix well. A v-shaped mixing device can be used. In this process, we should control the relevant process parameters, such as one-time addition and mixing time, to ensure uniform mixing; The research shows that magnesium stearate mixed with particles has high strength and long time. Magnesium stearate increases its specific surface area due to the interaction between particles, enhances the hydrophobicity of tablets, and affects its properties. The best process parameters need to be obtained through experiments and implemented in production.

Calculate the tablet weight, and then tablet. The calculation method of tablet weight is mostly to measure and obtain the content of main drug in the mixture of granules and related excipients, and then calculate the theoretical tablet weight, that is, tablet weight = the content of main drug per tablet/the percentage of main drug in the mixture of granules.