Does the use of anticancer drugs affect normal cell division?

Because the principle of most anti-tumor drugs is to inhibit cell proliferation in different ways; Because inhibition of cell proliferation is equivalent to inhibition of tumor growth and diffusion, thus achieving anti-tumor effect. regrettable

Most drugs have no selectivity and are equally lethal to normal cells.

As mentioned above, paclitaxel and vinblastine are the same, which not only affect cell division in tumor cells, but also in normal cells. The specific harm is manifested in hematopoietic inhibition and bone marrow inhibition (these physiological links need normal cell division). Other toxic and side effects, such as gastrointestinal reaction and neurotoxicity, are related to the nature of drug molecules, but have little to do with anti-proliferation.

Searching for selective antitumor drugs has always been the direction of efforts and the focus of research. It includes gene therapy, targeted drug delivery and highly selective cytotoxic drugs, but they are far from reaching the level of clinical application.

Finally, I'd like to mention a direction I'm currently studying, angiogenesis inhibitors. In addition to growth, division and proliferation, tumors need new blood vessels to provide nutrition for further expansion, which inhibits angiogenesis and makes tumors lack nutritional sources, which is equivalent to starvation of tumors. The toxic and side effects are very small, because normal adults rarely need angiogenesis, generally only during the recovery period or during the menstrual period of women. Relatively speaking, the consequences are acceptable and the selectivity is better.