Introduction of Loxapine

Table of Contents 1 Pinyin 2 English Reference 3 Loxapine Instruction 3.1 Name of the Drug 3.2 English Name 3.3 Alias of Loxapine 3.4 Classification 3.5 Dosage Forms 3.6 Pharmacological Actions of Loxapine 3.7 Pharmacokinetics of Loxapine 3.8 Indications for Loxapine 3.9 Contraindications to Loxapine 3.10 Precautions 3.11 Adverse Reactions of Loxapine 3.12 Dosage of Loxapine 3.13 Interactions between Loxapine and Other Drugs 3.14 Expert Commentary 3.15 1 Pinyin

luò shā píng

2 English Reference

Loxapine [Landau Chinese-English Dictionary]

3 Instruction Manual of Loxapine 3.1 Name of the Drug

Loxapine

3.2 English Name

Loxapine

3.3 Synonyms

Loxapine Hydrochloride

3.4 Dosage and Dosage

Loxapine Hydrochloride

4. Synonyms

Loxapine hydrochloride; Ketiazepine; Loxapine

3.4 Classification

Neurological Drugs > Antipsychotic, Antidepressant, Antianxiety Drugs > Others

3.5 Dosage forms

1. 5mg, 10mg, 15mg, 20mg;

2. Injection: 500mg (10ml).

3.6 Pharmacological effects of loxapine

Loxapine is a dibenzoxazepine antipsychotic, similar to chlorpromazine.

3.7 Pharmacokinetics of loxapine

Loxapine is rapidly absorbed orally and undergoes rapid and extensive first-pass metabolism. The metabolites are excreted in the urine mainly in bound form, and a small amount is excreted in the feces as unconjugated metabolites. A large portion of the metabolite can be excreted within 24h after each administration. The major metabolite is the active 7- and 8-hydroxyloxapine, which can be bound to glucuronic acid or sulfuric acid. Loxapine is widely distributed in the body and can cross the placenta and enter breast milk.

3.8 Indications for loxapine

Treatment of psychosis.

3.9 Contraindications to loxapine

Contraindicated in those who are allergic to loxapine, pregnant women, breastfeeding, the rest see clozapine.

3.10 Precautions

(not known)

3.11 Adverse effects of loxapine

1. Its incidence of extrapyramidal symptoms and sedation is intermediate between that of chlorpromazine and phenothiazine with a piperazine side chain.

2. Other adverse reactions are nausea, vomiting, seborrhea, dyspnea, ptosis, headache, abnormal sensation, flushing, weight gain or loss, and irritable thirst.

3.12 Dosage and administration of loxapine

1. 20 to 50mg per day in 2 divided doses, after 1 week, the dose is gradually increased to 60 to 100mg per day or more on the 8th to 10th day in 2 to 4 divided doses, with a maximum dose of 250mg per day. the maintenance dose is usually 100mg per day.

2. In order to control the acute symptoms: intramuscular injections of 12.5-25mg at 4-6h (or longer) intervals.

3.13 Drug interactions

Clozapine

3.14 Expert opinion

The clinical use of the synthesis of "atypical neuroleptics", represented by clozapine, has opened up a new field of psychiatric treatment. One such drug is loxapine. Lozapine has a similar chemical structure to clozapine, and its pharmacologic mechanism, clinical efficacy, and adverse effects are similar to those of the traditional antipsychotic chlorpromazine.

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