Therapeutic mechanism of specific immunity

1. Regulatory T cells regulate the function of helper T cell subsets (th1/TH2); 2. "Blocked antibody" theory: This theory holds that IgG can competitively block the combination of allergen and IgE on the surface of mast cells, thus avoiding the activation of mast cells and the release of inflammatory mediators; 3. Regulation of 3.IgE; 4. Inhibition of effector cells and inflammatory reaction; 5. Modified dendritic cells (DC) induce immune tolerance; 6. Induce peripheral tolerance, that is, the antigen-specific T cell disability induced by IL- 10 can form peripheral tolerance; 7. Regulatory function of regulatory T cells (CD4+CD25+Tr cells).

The mechanism of SIT is complex, and different immunotherapy mechanisms are different, depending on the nature of allergens, tissues and organs involved in the disease, immunotherapy methods, dosage and duration, adjuvant types used and individual heredity. Therefore, it is of great significance to clarify this mechanism to improve the clinical efficacy and safety of SIT.