Zhongjing Liuwei Dihuang Pill II. Concentrated pill form

The production technology of different dosage forms of Liuwei Dihuang Pills is different. The preparation process of traditional dosage forms such as watered pills, honeyed pills and honeyed pills is relatively simple, and only six kinds of medicinal materials need to be crushed into fine powder, mixed evenly, and made into pills with water, water and honey as binders respectively. The preparation process of tablets, granules and capsules of Liuwei Dihuang is as follows: pulverizing some medicinal materials into fine powder; Decocting a part with water, and concentrating into paste; Mixing the paste and powder to make Chinese medicine. Most of these traditional dosage forms take raw powder of medicinal materials as medicine, and from the point of view of pharmacokinetics, the absorption is poor and it is difficult to ensure the curative effect; Large dosage and short shelf life can not meet the needs of modern people.

In the modern production technology of Liuwei Dihuang Pills, the production technology of soft capsules has changed greatly. Except the volatile oil extracted from Cortex Moutan, all the other medicinal materials are extracted by ethanol, which is quite different from the traditional decoction method. The clinical application history of Liuwei Dihuang decoction for nearly a thousand years also proves that its water-soluble components have remarkable curative effect, and whether alcohol extraction is a suitable extraction method needs further study.

The production process of concentrated pills consists of three parts-extract, powder and effective components extracted scientifically. These three parts have made a qualitative leap compared with traditional water pills and honey pills. Modern research has proved that paeonol is the main effective component of Cortex Moutan in Liuwei Dihuang Pill, which is volatile. If decocted or directly used as powder, it may evaporate during the manufacturing process. Therefore, paeonol is extracted separately in the production process of concentrated pills and then added in the final pill making process.

For other medicinal materials that contain volatile active ingredients and need special treatment, Wanxi Pharmaceutical has also adopted CO2 supercritical extraction technology and macroporous resin adsorption technology that meet international standards to extract and maximize the purification and retention of active ingredients. 1, remove the essence and absorb it well. According to the relevant data, the absorption rate of traditional Chinese medicine pills is ranked as follows:

Concentrated pills > water pills > millet pills > honey pills, which means Liuwei Dihuang concentrated pills have the best absorption rate. Only by fully absorbing the effective components in traditional Chinese medicine can traditional Chinese medicine play its due role.

2, sugar-free, more suitable for diabetic patients. It is safer for diabetics and sugar-forbidden patients to use sugar-free drugs. Traditional honey pills and honey pills use water and honey as binders, while Liuwei Dihuang concentrated pills use concentrated extract as binders, which contains no sugar and is more suitable for diabetics.

3, easy to carry. Take 8 concentrated pills each time, 3 times a day, about 1.5g, especially suitable for the fast-paced life of modern people. The traditional honey pill takes 9 grams each time, which has a particularly poor taste and is easy to leave a medicinal taste in the mouth; Take 6 grams of water pills and honey pills each time, and hold one in your hand. Eating it several times is not easy for young people to accept.

4. The quality is stable. After each process, Liuwei Dihuang concentrated pills have stable quality and long shelf life, while the shelf life of traditional honey pills and small honey pills is generally short.