Characteristics of evidence-based medicine compared with traditional empirical medicine

The core of evidence-based medicine is to develop traditional medicine based on experience into modern medicine based on science. Treatment methods also range from treating "human diseases" to treating "sick people".

The biggest feature of evidence-based medicine is that when evaluating the effectiveness and safety of treatment, it is necessary to take the related quality of life and prognosis of patients as the end point index-clinical outcome, and conduct large-scale, multi-center and randomized controlled trials. For example, in cardiovascular field, nifedipine is a widely used antihypertensive drug at home and abroad. Traditional medical model research has proved that it can effectively lower blood pressure and has no adverse effects on organs such as liver and kidney. Evidence-based medical evidence shows that nifedipine can effectively lower blood pressure, but it will increase the risk of myocardial infarction. The greater the dose and the longer the course of treatment, the more obvious the risk will increase. The difference between the two medical models is that the traditional medical model only evaluates the antihypertensive effect and adverse reactions of drugs, while evidence-based medicine evaluates the influence of patients on "life and death" and "heart attack" after using drugs. Therefore, this evaluation of evidence-based medicine is called "prognosis" evaluation.

The idea and strict methodology of evidence-based medicine put forward new ideas and higher requirements for pre-clinical research and pre-marketing clinical research of drugs. Advocating evidence-based medicine is helpful to improve the quality of drug clinical research, not only to guide the research and development of new drugs, but also to evaluate drug technology, and to further explore how to evaluate evidence-based drugs and really improve the quality of drug evaluation.