What are the well-known foreign mass spectrometer manufacturers? What about domestic ones

Why didn't anyone answer this question? Who are the well-known mass spectrometer manufacturers at home and abroad?

In recent years, with the rapid development of science and technology, mass spectrometry has become the most popular instrument. What the hell was the mass spectrum yesterday? Some people say that mass spectrometry is widely used in chemistry, chemical engineering, medical clinical examination, pharmaceutical research, environmental monitoring and so on. There is a great demand in China. Only in the field of medical clinical testing, the market valuation of mass spectrometry server is as high as125 billion blue ocean market. Newborn genetic screening, vitamin D testing, microbial diagnosis, drug testing and other testing fields, the corresponding market space is 2.2 billion yuan, 7.6 billion yuan, 265.438+0 billion yuan, 600 million yuan respectively. But now there are many mass spectrometer manufacturers, and the homogenization of low-end mass spectrometry is a big problem. Mass spectrometers are classified, including LC-MS/GC-MS, MALDI-TOF, ICP-MS, ion trap (QTOF MS) and so on. Among them, triple quadrupole tandem mass spectrometry and time-of-flight mass spectrometry are widely used, with great demand and the fiercest market competition.

At present, the main brands in the mass spectrometry market are international brands Agilent, AB SCIEX, PerkinElmer, Shier of Thermo Fisher Scientific Shier Technology, Brooke (BD cooperative agent), Waters, Meria (Shimadzu) and so on. Domestic brands include Shandong Yingsheng, Guangzhou Fenghua, Tian Rui Instruments, Guangzhou Darui, Antu and Yixin Bochuang. Xiao Ran recommended the brands and products of mass spectrometer manufacturers popular in China market.

Meria

Bio-Meria was founded in 1963. Its diagnosis system consists of reagents, instruments and software, and it is mainly designed around four strategic areas, namely infectious diseases, industrial microbial control, cardiovascular diseases and tumors.

The VITEK MS automatic microbial mass spectrometry detection system developed by Meria can accurately identify bacteria to the species level in a few minutes by using MALDI-TOF technology. The database containing 65,438+05,000 strains and advanced map classification algorithm provide accurate diagnosis report for clinic.

MALDI-TOF MS market has been occupied by Bio-Meria and Brooke, and its shipment volume is about 1: 1. Time has entered 20 18, and the biggest change in the market is the price reduction of Bio-Meria!

Last year, VITEK MS, with a general unit price of 27,000-29,000 yuan, won the transaction price of 654,38+0.5 million yuan for many times in the bidding news of 2065.438+08, and the price reduction was amazing.

For the price reduction of Meria, some insiders believe that "the price war has started, and the microbial mass spectrometry may drop to less than one million yuan this year. If you don't sell this price, there will be no business. "

Bian Xiao predicted that the price reduction was intended to occupy the rapidly growing microbial mass spectrometry procurement market in China, which was mainly made up of top-three hospitals and local CDC in first-tier cities.

Brooke

As one of the leading analytical instrument companies in the world, Brooke introduced the first commercial MALDI-TOF mass spectrometer in 1992.

MALDI-TOF and TOF/TOF MS mass spectrometers newly introduced by Brook Company are powerful tandem mass spectrometers established as protein depth analysis methods, and they are well-known in the industry for their ultra-high performance, stability and innovative design.

Shimadzu

Shimadzu is a famous manufacturer of test instruments, medical instruments and industrial equipment. In recent years, the investment in mass spectrometry market has been continuously increased, and a number of new UFMS series mass spectrometry products have been continuously introduced, such as four-bar time-of-flight mass spectrometry LCMS-9030, high-sensitivity triple quadrupole GCMS-TQ8050, inductively coupled plasma mass spectrometry ICPMS-2030, etc. According to statistics, the China mass spectrometer of Shimadzu Company reached 1000 in 20 17.

Waters

Waters liquid chromatography and mass spectrometry products are favored by scientists all over the world, and have been in the industry for more than 50 years, and now they have become one of the largest companies in the analytical instrument industry.

Waters' latest gas chromatography-mass spectrometry/mass spectrometry (GC-MS/MS) system for food safety analysis and direct analysis mass spectrometry system for fast molecular fingerprint analysis of finished food, raw materials and semi-finished products are specially developed to meet various analysis needs of food testing institutions, universities and laboratories of biomedical research institutions.

SCIEX

Sciex has been focusing on cutting-edge instruments, workflow solutions and supporting innovation for 40 years, and is a leader in the field of tandem mass spectrometry. The 4500MD series mass spectrometer developed by the company is a flexible LC-MS/MS platform, belonging to the triple quadrupole mass spectrometer. Its performance is better than that of 3200MD system, and it has better sensitivity and faster data acquisition speed, and can realize high-confidence quantitative analysis.

Another 3200MD mass spectrometer system is an affordable desktop platform with high sensitivity, low detection limit and high specificity, which can bring better data (compared with traditional technology) and greatly reduce the time and cost required for routine clinical diagnostic tests.

Agilent technology co., ltd

Agilent is a global leader in analytical laboratory technology and has accumulated more than 40 years of professional experience in the field of mass spectrometry. Its products mainly include gas chromatography-mass spectrometry (GC/MS) system and liquid chromatography-mass spectrometry (LC/MS) system.

Agilent 6495B Triple Quadrupole LC/MS System

Yingsheng biology

Yingsheng Bio was established in 2009, and built a one-stop mass spectrometry detection platform in the industry, including artificial intelligence pretreatment platform, mass spectrometry Qualcomm detection, cloud processing data analysis and so on. In 20 13, a screening kit for neonatal genetic and metabolic diseases based on tandem mass spectrometry platform was developed, which was the first in China. 20 15 developed a full-spectrum vitamin detection kit, which is exclusive in China.

On July 18 and 10, Yingsheng Bio signed a strategic cooperation agreement with Thermo Fisher Scientific Shier Technology to establish a mass spectrometry medical equipment production base in Jinan, and promote the localization of mass spectrometry equipment through complementary advantages.

Yi Xin bo Chuang

Yixin Bochuang's flight mass spectrometry is the first instrument in China to obtain the second-class instrument registration certificate, and has been extended to gene detection, sugar detection and so on.

As the first clinical time-of-flight mass spectrometry enterprise in China to obtain CFDA registration certificate, Yixin pioneered and realized a single-machine multi-platform in the world, and developed the only multi-purpose platform in the world-Clin-TOF time-of-flight mass spectrometry system. One machine can meet the clinical application in four fields: microorganism, protein, gene and sugar.

At present, the system has built the world's first microbial mass spectrometry cloud center through the microbial mass spectrometry database of more than 370 genera, 2,200 species and 8 100 strains based on Flora of China, and the database has been clinically verified to be more than 200,000 strains.

Antu biology

Microbial detection is the second main business of Antu biological tradition. The company mainly relies on the sales channels of existing products to enter the microbial diagnosis market faster and more effectively.

Antu's Autof MS 1000 is expected to become a microbial Malditov clinical mass spectrometer with the qualification of both microbial database and clinical sample detection in China, and it will be released quickly in the original channel.

In addition to these manufacturers, He Xin Mass Spectrometry, Tian Rui Instruments and East-West Analysis all specialize in mass spectrometry, not limited to flight mass spectrometry, but also liquid mass spectrometry and gas mass spectrometry, and their medical properties are not obvious.

Rong Zhi Biology is a flight mass spectrometry specialized in microbial detection, but it is difficult and time-consuming to apply for the registration certificate of three types of instruments, and the journey to the hospital is still early. It is expected to start from the low threshold industry of food microbiology.

In the field of mass spectrometry, in addition to the above-mentioned production enterprises, there are also a number of agents and service providers, such as Odie Innovation's exclusive agent for Jevak liquid chromatography and mass spectrometry instruments and reagents in the United States. Lin of the company is always an old inspector with more than 20 years' experience and asked him many professional questions about mass spectrometry.

Ou Di innovation

The United States was founded in 2005 and has a production base in Europe. Its products mainly involve the development of LC-MS/MS and HPLC diagnostic test kits and liquid chromatography systems, as well as mass spectrometry sample pretreatment systems and analysis software.

Javak multi-task mass spectrometer preprocessor is the first processing instrument in the world to realize full automation of mass spectrometer. It can be directly connected to the mainstream liquid mass spectrometer in the market, reducing manual operation steps and realizing the whole process detection automation of mass spectrometry.

Dean's diagnosis

In 20 17, Dean Diagnostics signed a cooperation agreement with SCIEX, a mass spectrometry manufacturer owned by Danaher, and announced that * * * had established a joint venture company Disses Diagnostics to jointly promote mass spectrometry technology in China.

The first phase of Diesel Diagnostics will focus on developing, registering and selling Class I, Class II and Class III instruments and in vitro diagnostic reagents/kits for 4500MD or other Sciex instruments.

Jinyu medicine

Jinyu Medicine is an early service provider in the field of mass spectrometry detection in China. In 2008, the company gradually laid out the clinical detection of mass spectrometry. At present, about half of the laboratories can provide mass spectrometry detection including neonatal screening, vitamin D and drug concentration detection.

Brief introduction of mass spectrometer manufacturers in the future?

Although China's mass spectrometry market started late compared with North America and Europe, it has great development potential. Unlike some domestic instruments that can be used to compete with imported instruments, mass spectrometer is still the weak link of domestic instruments. But we are glad to see that more and more domestic manufacturers are turning their attention to mass spectrometry, and the country is paying more and more attention to mass spectrometry. We have reason to believe that domestic mass spectrometry will "break through" foreign brands and occupy a place in the market. In the next decade, China's mass spectrometry market will be "a fierce battle". Finally, who is the biggest winner, let's wait and see!

Reference: In vitro diagnosis