Cefixime Capsules

Open Classification: Drugs, Western Drugs, Chemicals

Generic Name: Cefixime Capsules

English Name: Ceriwime Capsules

Ingredients: the active ingredient of this product is cefixime

Properties: this product is a hard capsule, the contents of which is a white or yellowish powder after removing the capsule.

Pharmacology and toxicology: this product is the third generation of oral cephalosporins, through the inhibition of bacterial cell wall synthesis and bactericidal effect. It is stable to most B-lactamases, and many strains of penicillinase- and cephalosporinase-producing bacteria are still sensitive to this product. Cefixime has good bactericidal effects in vitro and in vivo against Gram-positive cocci such as pneumococci, Streptococcus pyogenes, and Gram-negative bacilli such as H. influenzae (including enzyme-producing strains), C. catarrhalis (including enzyme-producing strains), E. coli, S. peculiaris, and Gonococcus (including enzyme-producing strains). Cefixime also has bacteriostatic activity in vitro against Pneumococcus, Parainfluenza, Proteus, Klebsiella pneumoniae, Pasteurella multocida, Prevotella, Salmonella, Shigella, Salmonella, and Salmonella heterozygous citrobacter, but its clinical effectiveness has not been established. It has poor antibacterial effect on Staphylococcus, and no antibacterial effect on Pseudomonas aeruginosa, Enterobacteriaceae, Clostridium perfringens, and Clostridium perfringens. Pharmacokinetics: about 40%-50% absorption after oral administration of the product. The time to peak blood concentration after oral administration is 2-4 hours. Serum protein binding rate is 70%. The apparent volume of distribution is 0.11L/kg. half-life is 3-4 hours. It is well distributed in the body after oral administration and can enter the fetal circulation through the placenta.About 20% of the administered dose is excreted in urine within 24 hours. Hemodialysis or peritoneal dialysis cannot remove the product.

Indications: This product is indicated for pharyngitis, tonsillitis, acute bronchitis, acute exacerbation of chronic bronchitis, otitis media, urinary tract infections, simple gonorrhea (cervicitis, urethritis) caused by sensitive bacteria.

Use and dosage: Adults 200mg per day, can be single or divided into two oral. Doubling in severe cases. Children weighing ≥50kg or aged ≥12 years use the adult dose. Children 1.5-3.0 mg/kg daily, doubled in severe cases 400 mg single dose therapy is recommended for the treatment of simple gonorrhea.

ADVERSE REACTIONS: Adverse reactions are mostly transient and mild. Mainly diarrhea, fecal abnormalities, headache, nausea, abdominal pain, rash, etc., very few patients with elevated GPT, GOT. (See product description)

Contraindications: contraindicated in those with a history of hypersensitivity to the product or cephalosporin antibiotics.

Precautions:

1, patients with a past history of penicillin allergic shock should be cautious of using this product, patients with enteritis should be cautious of using it, and it is not suitable for children under 6 months.

2, renal insufficiency patients with prolonged serum wee decay, must adjust the dose.

3, pregnant and lactating women should be used with caution, patients of advanced age should be used with caution.

Overdose: There is no definite clinical information.

Packing specification: aluminum foil and PVC plate (1) 100 mg/capsule, 8 capsules per plate; (2) 50 mg/capsule, 6 capsules per plate;

Storage: Shielded from light, sealed, and stored in a cool, dark place.

Expiry date: 3 years.

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