Gene detection of chemotherapy for colorectal cancer can adjust the dose and improve the curative effect.

Patients with advanced colorectal cancer need to receive traditional chemotherapy after diagnosis; According to the research, 3% of patients with colorectal cancer will have gene mutation after UGT 1A 1 gene detection. For the traditional chemotherapy drug irinotecan, the dosage should be reduced to reduce the toxicity. As for those without gene mutation, the dosage can be increased to improve the therapeutic effect. This study is a retrospective analysis of 7 2 cases of advanced colorectal cancer made by Wang Zhaoyuan, director of gastrointestinal and general surgery in the Affiliated Hospital of Kaohsiung Medical University. The results showed that UGT 1A 1 is an enzyme existing in human liver, and the gene UGT 1A 1 can detect the ability of UGT 1A 1 to metabolize irinotecan, and about 3% patients with colorectal cancer will have the gene. Director Wang Zhaoyuan said that irinotecan combined with target drug is the first-line treatment for advanced colorectal cancer, and irinotecan is mainly metabolized by liver enzyme UGT 1A 1 in human body. If the gene mutation of UGT 1A 1 occurs, the drug concentration will accumulate when irinotecan is used, which is easy to produce acute toxic symptoms such as delayed diarrhea and leukopenia. Director Wang Zhaoyuan further pointed out that for patients with intestinal cancer with UGT 1A 1 gene mutation, the dosage of irinotecan should be reduced to avoid toxicity. For those with no mutation in UGT 1A 1 gene, the dosage can be increased to improve the therapeutic effect. This study has been published at this year's annual meeting of American Cancer Medicine; Director Wang Zhaoyuan said that a prospective study will be conducted next, and 320 patients with intestinal cancer will be called in 10 hospitals for UGT 1A 1 genetic testing, which is expected to start at the end of this year. Subscribe to the health Aloha audio-visual channel, read health knowledge more easily, and pay attention to your health every day! Line @ ID: @:/cancer/article/10849/Cancer chemotherapy gene detection adjustable dose to increase curative effect Keywords: colon cancer, chemotherapy, gene detection, UGT 1A 1, irinotecan, Affiliated Hospital of Kaohsiung Medical University.