What is a traditional C5 invertase?

Chinese name: C5 invertase English name: C5 convertase

Definition: Key invertase formed when complement is activated.

The C5 invertase in the classical (traditional) activation pathway is C4b2a3b.

The C5 invertase in the bypass (substitution) activation pathway is C3bBb3b.

C5 invertase can split C5 into C5a and C5b fragments. C5b combines with C6 and C7 in liquid phase to form C5b67, which is embedded in the hydrophobic lipid layer of cell membrane, and then polymerized with C8 and part of C9 molecules to form C5b6789n complex, that is, membrane attack complex.