What are the difficulties in selecting scaffold materials for bone tissue engineering?

Effective adhesion and biocompatibility are achieved between scaffolds and biological tissues, and different types of tissues have different physical and chemical characteristics.

1. Tissue engineering scaffold materials refer to materials that can combine with living cells of tissues, can be implanted into different tissues of organisms, and can replace tissue functions according to specific conditions. The difficulty of selection lies in: achieving effective adhesion and biocompatibility between scaffold and biological tissue, and the growth of biological tissue needs complex microenvironment, such as signal molecules, extracellular matrix, growth factors and so on.

2. Different types of tissues have different physical and chemical characteristics, so it is necessary to design and manufacture scaffolds for different tissue types.