Does anyone know the process of making large honey pills of traditional Chinese medicine?

I. Classification of Chinese medicine pills

Chinese medicine pills are spherical or spherical-like preparations made of fine powder of medicinal herbs or extracts of medicinal herbs plus suitable binder or other excipients, which are classified into the types of honey pills, water honey pills, water pills, pasted pills, wax pills and concentrated pills. Chinese herbal medicines can be extracted, purified and concentrated by suitable methods with suitable matrix to make drop pills, such as Compound Danshen Drop Pills.

Concepts related to honey pills, water honey pills, water pills, paste pills, wax pills and concentrated pills.

The characteristics of Chinese medicine pills: slow drug release, slow and long-lasting effect, can reduce the toxic side effects; can hold more semi-solid or liquid drugs; can be coated to mask the bad smell of the drug, to improve the stability of the drug; the preparation method is simple. However, some varieties of large dosage, pediatric swallowing difficulties, low bioavailability and other problems.

Two, the preparation of Chinese medicine pills

(a) auxiliary materials

The preparation of Chinese medicine pills commonly used auxiliary materials: wetting agent (water, wine, rice vinegar, water honey, medicine juice, etc.), adhesive (honey, rice paste or batter, herbs, clear (soaked) paste, syrup, etc.) and absorbing agent (mainly powdered herbs).

Honey is an important part of honey pills, which not only plays the role of binder, but also nourishes, moistens the lungs, moistens the intestines, detoxifies and flavors the body.

The preparation of honey pills can be based on species, climate and other specific conditions of the use of refined honey.

(B) the preparation method

The preparation method of Chinese medicine pills mainly include plastic and pan system. Chinese medicine pills drop method.

1. Plasticizing method

The powdered herbs are mixed with suitable excipients (mainly wetting agents or adhesives) to make plastic pill blocks, and then rolled, divided and rounded into pills. The plasticizing method is mainly used for the preparation of honey pills and paste pills. Different equipments are used in each step of the above process, mainly including kneading machine for making pill blocks, pill strip machine for making pill strips, and pill rolling machine for splitting and rounding. At present, there are ZW-80A type and ZW-40A type automatic pill making machine for traditional Chinese medicine. ZW-80A type automatic pill making machine for traditional Chinese medicine mainly consists of feeding hopper, propeller, self-control wheel, guide wheel, pill making knife wheel and nozzle, etc. The machine can be operated by the following equipment.

Operation, will have been mixed into the conical pill block hopper, in order not to overflow the hopper and not less than 1/3 of the height of the hopper cone appropriate to avoid fluctuations in the degree of densification of the drug strip. The material is pushed out by the spiral propeller extrusion into the pills, under the control of the guide wheel, the pills synchronized into the relative direction of rotation of the pill knife wheel, due to the radial and axial movement of the pill knife wheel, the pills will be cut and rolled round, the process of making pills by the nozzle spraying ethanol lubricating effect.

2. Pan system method

Pan system method is the drug powder and wetting agent or adhesive alternately added to the appropriate equipment, so that the pill layer by layer to increase the method. Pan system method is mainly used for the preparation of water pills, water honey pills, paste pills, concentrated pills, etc., the production of coating pots and small pills continuous pill machine and other equipment.

Three, quality inspection

The quality inspection of Chinese medicine pills mainly includes: appearance, moisture, loading, loading difference, weight difference, dissolution time limit, microbial limit and so on.