How is neuralgia caused? What medicine works? Thank you for your questions.

Neuralgia is the abbreviation of neuropathic pain, which is not induced by injury or disease stimulation, but by abnormal nerve discharge. Neuropathic Pain Due to the neuroplasticity changes of the central nervous system, traditional painkillers, such as opioids and non-steroidal anti-inflammatory drugs (NSAIDs), are ineffective in treating neuralgia. With the development of science, a new generation of therapeutic drugs, calcium channel modulator (pregabalin), has appeared, which can reduce the excessive release of excitatory neurotransmitters by regulating over-excited neurons, and has been recommended as a first-line drug for the treatment of neuropathic pain by guidelines issued by several international medical associations, including the American Neurological Association (AAN). A few days ago, on World Analgesia Day, Sohu had an expert interview with Professor Xu Jianguo, Chairman of the Pain Medicine Committee of the Chinese Medical Association. He introduced the pathology and treatment of neuralgia, which can be referred to as /s20 10/pain20 10/