Pathological theory guidance: posthumous cirrhosis

Necrotic cirrhosis, equivalent to macronodular cirrhosis and mixed cirrhosis of large and small nodules, is formed on the basis of a large number of necrosis of liver parenchyma.

I. Reasons

1. Hepatitis virus infection is usually called HBV infection, and there are also mixed infections of HBV and HDV. VEV infection mainly occurs in pregnant women. Most patients suffer from subacute severe hepatitis, and if the course of the disease is prolonged for several months to more than one year, necrotizing cirrhosis will gradually form. In addition, the recurrence and necrosis of chronic active hepatitis can also be caused.

2. Drug and chemical poisoning.

Second, the disease.

Macroscopically, the size, weight and texture of the liver have become smaller. There are large nodules of different sizes on the surface, and the diameter of the nodules can reach 6cm. Due to the formation of nodules of different sizes, the liver is often deformed, the left lobe of the liver is obviously atrophied, and the right lobe is relatively hypertrophy and uplift.

The size of the liver is reduced, and there are nodules with different thickness on the surface. Microscopically, the hepatic lobule showed focal, banded or even whole lobule necrosis, replaced by fibrous tissue proliferation, forming gaps, which divided the original hepatic lobule into false lobules of different sizes. Liver cells in pseudolobules often show different degrees of degeneration and cholestasis. The fiber spacing between pseudolobules is wide and the thickness is uneven, among which inflammatory cell infiltration and small bile duct hyperplasia are more obvious, which is different from portal cirrhosis. However, this kind of disease progresses slowly, and it is difficult to distinguish it from portal cirrhosis with a long course of disease.