What is myocardial enzyme profile?

When inflammation (myocarditis) or necrosis (myocardial infarction) occurs in the heart muscle cells due to various reasons, the enzymes contained in the heart muscle cells enter the bloodstream, and the activity (content) of these enzymes in the blood increases. There is no single enzyme used to help diagnose heart disease, so it is called a "myocardial enzyme profile".

The cardiac enzyme profile includes: creatine phosphokinase (CK), creatine kinase isoenzyme (CK-MB), aminotransferase (AST), lactate dehydrogenase (LDH), lactate dehydrogenase isoenzyme (LDH1, LDH2), and a-hydroxybutyrate dehydrogenase (a-HBDH).

In addition, cardiac troponin T (cTn) is a highly specific and sensitive indicator of myocardial injury, especially in myocardial infarction with early appearance, high value and long duration, and it is an important indicator for the diagnosis of myocardial injury diseases such as acute myocardial infarction. Therefore, many hospitals have listed cTn and cardiac enzyme profile*** as related test items.

So, what conditions need to check the cardiac enzyme spectrum?

1, occurred in the upper respiratory tract infection or other infections (such as viral hepatitis, gastrointestinal viral infections manifested as vomiting, diarrhea, etc.) and pregnancy or post-partum, panic, shortness of breath, cardiac rhythm disorders, chest pain, and other symptoms, may occur in myocarditis.

2. Those who have been diagnosed with myocarditis -, observe the changes in their condition.

3, suspected or diagnosed as a recent myocardial infarction, but myocardial enzyme profile can not be used alone as a basis for diagnosis.

Besides, myocardial enzyme profile also has limitations:

1, myocardial enzyme profile of the enzymes can also be elevated in many other diseases, such as hepatitis, extrusion syndrome, etc., so to make the diagnosis of myocardial damage must be combined with clinical.

2, myocardial inflammation or myocardial infarction in different stages of the disease, a variety of enzymes rise, fall to normal in different patterns.

3, the normal value of the test in each hospital varies depending on the method, and the reference (normal) value of the testing hospital should be requested for comparison.

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